铜绿假单胞菌临床分离株的耐药性分析

Analysis of the Antibiotic Resistance of Isolated Clinical Pseudomonas Aeruginosa Strains

目的:分析242株铜绿假单胞菌(PA)的临床来源分布及耐药现状,为临床预防医院感染及合理应用抗生素提供依据。方法:标本获得纯培养后,用法国bio.Merieux公司的Vitek-AMS微生物全自动分析仪进行鉴定和药敏,药敏试验采用Vitek-AMS的Mic法与纸片琼脂扩散(K-B)法相结合的方法,以求结果更为精确。结果:PA所致的呼吸道感染是院内感染的重要途径。其对抗菌药物表现为多重耐药性;敏感率最高的抗生素是亚胺培南(90.1%),其次为哌拉西林他唑巴坦(85.9%)。左氧氟沙星与环丙沙星(83.1%与81.4%),妥布霉素(83.1%),头孢三代的头孢他啶和四代的头孢吡肟也有颇高的敏感率(75.6%和74.4%);而耐药率最高的是头孢唑啉和头孢替坦(均为98.8%)。次为氨苄西林(91.7%)、复方新诺明(90.1%)及头孢曲松(64.9%)。结论:必须健全医院消毒隔离制度,预防PA的医院感染,且根据药敏试验结果合理选用抗生素。以遏止其耐药率的攀升。

Objective Analyse the source,the distribution and the resistance of 242 strains of Pseudomonas aeruginosa to use antibiotics rationally and prevent nosocomial infections.Methods Used vitek-AMS in identification and made the antimicro- bial susceptibility test which cultured strains were from obtained samples.Results Respiratory infection which is caused by PA is the most improtant way of nosocomial infections.The multi-resistance of PA is very serious.They are resistant to Piperacilin, Ceftazdime,Cefepime,Aztreonam,Tobramycin,Gentamicin,Levofloxacin and Ciprofloxacir.Conclusion We should perfect the disincentive system of the hospital to prevent nosocomial infections.And doctors should choose antibiotics rationally in dealing with the PA infected patients according to the antimicrobial susceptibility test.