摘要
目的:探讨门脉高压性胆病的发病机制。方法:采用病例对照研究法,25例肝硬化合并胆石症患者为胆石组,30例肝硬化无胆石症患者为对照组。比较两组患者的血清总胆汁酸、胆囊非特异性炎症、脾肿大程度。结果:结石组患者的血清总胆汁酸的含量显著高于对照组(P<0.01)、胆石组患者的胆囊非特异性炎症、脾肿大程度与对照组的差异有统计学意义(P<0.01)。结论:门脉高压性胆病的发病机制可能与血清胆汁酸代谢异常、胆囊非特异性炎症、脾亢等因素有关。
Objective To investigate the pathogenesis in patients with portal hypertensive cholelithiasis.Methods A control study was performed to compare two cirrhotic groups:25 cases with gallstone(gallstone group),30 cases without gallstone(control group).Results The serum total bile acid(TBA) concentration was higher in the gallstone group than in the control group(P<0.01);the difference of non-specific inflammation of gallbladder,and splenomegaly between two groups were statistically significant(P<0.01).Conclusion The pathogenesis of portal hypertensive cholelithiasis may be concerned with metabolic of disturbance of bile acid,non-specific inflammation of gallbladder and splenomegaly.
出处
《实用医技杂志》
2008年第6期681-682,共2页
Journal of Practical Medical Techniques
关键词
肝硬化
胆石症
发病机制
Cirrhosis of liver
Cholelithiasis
Pathogenesis
