替吉奥+顺铂与表柔比星+顺铂+5-氟尿嘧啶化学治疗方案治疗胃癌的成本及疗效对比研究

Comparison of the cost and efficacy of CS and ECF regimen in the treatment of gastric cancer

目的对比替吉奥+顺铂(CS)与表柔比星+顺铂+5-氟尿嘧啶(ECF)化学治疗方案治疗胃癌的成本及疗效,为临床合理选择胃癌方案提供依据。方法选取2014年6月至2015年5月我院收治的经病理诊断确诊的胃癌患者80例,按照化学治疗方法分成2组各40例,CS组采用顺铂+替吉奥治疗,ECF组采用表柔比星+顺铂+5-氟尿嘧啶治疗,采用药物经济学成本-效果分析法对2种化学治疗方案进行评价。结果 CS组化学治疗总有效率为45.0%(18/40),ECF组为42.5%(17/40),2组比较差异无统计学意义(P>0.05);2组化学治疗总有效率每增加1%所需费用分别为166.32元、134.41元,CS组明显高于ECF组(P<0.05);但随着成本的增加,CF组有着较高的成本收益比。结论 CS化学治疗方案成本较高,但是随着成本的增加,具有较高的成本收益比,在临床上患者应根据自身的经济能力选择合适的化学治疗方案。

Objective To compare the cost and efficacy of CS and ECF chemotherapy in the treatment of gastric cancer,and to provide a basis for clinical rational choice of gastric cancer.Methods from June 2014 to May 2015 in our hospital 80 cases of pathologically diagnosed gastric cancer patients with chemotherapy,according to the methods into two groups in all 40 cases,CS group were treated with cisplatin and S-1 treatment,group ECF was treated with epirubicin plus cisplatin and 5- fluorouracil,using pharmacoeconomic cost-effectiveness analysis of the two kinds of chemotherapy project evaluation.Results In CS group the total effective rate was 45.0%(18/40),ECF group was 42.5%(17/40),the two groups had no statistically significant difference(P>0.05).Two group total efficiency increased by 1 percentage points the costs were 166.32 yuan,134.41 yuan,CS group was significantly higher than that of group ECF(P<0.05).But with the increase in the cost,the CF group has a higher cost benefit ratio.Conclusion The cost of CS chemotherapy is high,but with the increase of cost,it has a high cost and benefit ratio,and the patient should choose the appropriate chemotherapy regimen according to their own economic capacity.