“加味培元固本散”对矽肺患者稳定期BODE指数的影响

Effects of “Flavored Peiyuanguben Powder” on the BODE Index in Patients with Silicosis

[目的]观察BODE指数评估"加味培元固本散"治疗矽肺稳定期患者的临床疗效。[方法]将符合纳入标准的101例矽肺患者随机分为治疗组(50例)和对照组(51例),治疗组予口服"加味培元固本散",对照组予安慰剂口服,两组均可按需予抗感染、止咳化痰、解痉平喘等西医综合处理,疗程3个月。比较各组治疗前后以及两组间的BODE指数评分变化,包括气流受限程度(FEV1%预计值)、功能性呼吸困难量表(MMRC dyspnea scale)、6min步行距离(6MWD)、体重指数(BMI)及对应积分。[结果]治疗前两组各因子指标及BODE指数积分比较变化不明显;治疗组治疗后BMI、6MWD、MMRC均有改善,BODE指数显著降低;与对照组比,治疗组治疗后BMI、6MWD、MMRC差异有显著意义。治疗后BODE指数显著低于对照组。[结论]加味培元固本散能促进矽肺患者BODE指数降低,改善矽肺患者预后。

[Objective]To observe the BODE index assessment ' Jiawei Peiyuan Guben medicinal powder' in Treating Silicosis Patients with stable clinical curative effect.[Methods]Will meet the inclusion criteria of 101 cases of silicosis patients were randomly divided into treatment group(50 cases)and control group(51 cases),the treatment group received oral ' Jiawei Peiyuan Guben medicinal powder',the control group received placebo orally,two groups can be required to fight infection,cough phlegm,antispasmodic and Western medicine treatment,a course of 3 months.The groups were compared between the two groups before and after treatment and BODE index changes,including the degree of airflow limitation(FEV1% expected value),functional Dyspnea Scale(MMRC dyspnea scale),6min walking distance(6MWD),body mass index(BMI) and the corresponding integral.[Results]Before treatment in two groups each factor index and BODE index integral comparison does not change obviously after treatment in treatment group;BMI,6MWD,MMRC were improved,the BODE index decreased significantly;compared with the control group,treatment group after treatment,BMI,6MWD,MMRC had significant difference.After treatment of BODE index was significantly lower than the control group.[Conclusion]Modified Peiyuan solid this powder can promote the BODE index decreased in patients with silicosis,improve the prognosis of patients with silicosis.