柴芍消痞汤治疗慢性萎缩性胃炎伴肠上皮化生随机平行对照研究

Chaishao Xiaopi Method Treating Chronic Atrophic Gastritis with Intestinal Metaplasia Randomized Controlled Study

[目的]观察柴芍消痞汤治疗慢性萎缩性胃炎伴肠上皮化生疗效。[方法]使用随机平行对照方法,将68例住院患者按抽签法随机分为两组。对照组34例胃复春,4片/次,3次/d,饭前半小时服。治疗组34例柴芍消痞汤(柴胡10g,白芍、枳壳各15g,法半夏10g,白花蛇舌草、延胡索、丹参各15g,田七10g,甘草5g)。阴虚加麦冬、石斛各15g;气虚加党参、北芪各15g,白术10g;湿热加黄芩15g,蒲公英30g。加水1200mL,煎制400mL,1剂/d,早晚两次,饭前30min服。连续治疗30d为1疗程。观测临床症状、症状控制时间、胃黏膜形态及病理(胃镜、病理)、不良反应。连续治疗3疗程,判定疗效。[结果]治疗组痊愈14例,有效18例,无效2例,总有效率94.10%。对照组痊愈10例,有效13例,无效11例,总有效率67.60%。治疗组疗效优于对照组(P<0.05)。症状控制时间治疗组优于对照组(P<0.05)。[结论]柴芍消痞汤治疗慢性萎缩性胃炎伴肠上皮化生疗效显著,值得推广。

[Objective] observed Chaishao Xiaopi Method treating chronic atrophic gastritis with intestinal metaplasia effect.[ Methods] Using randomized controlled method,68 cases of hospitalized patients were randomly divided into two groups.Control group of 34 cases of oral Weifuchun tablets,4 tablets / time,3 times / d,half an hour before meals.Treatment group 34 cases Chaishao Xiaopi Tang(Chaihu 10g,Baishao,Zhike each 15g,Fabanxia 10g,Baihua sheshecao,Yanhusuo,Danshen each 15g,Tianqi 10g,Gancao 5g).Subtraction with the disease: partial deficiency Maidong,Shihu each 15g;deficiency Dangshen,Beiqi each 15g,Baishu 10g;humid plus Huangcen 15g,Pugongying 30g.Add water to 1200mL,fried 400mL,1 does / d,morning and evening,before taking 30min.30d is a course of continuous treatment.Observation of clinical symptoms,symptom control time,endoscopy,adverse reactions.Continuous treatment of 3 courses,to determine efficacy.[Results] The cure 14 cases,effective in 18 cases,2 cases,the total efficiency of 94.10%.Control group cured 10 cases,effective in 13 cases,11 cases,total effective rate 67.60%.Treatment group than the control group(P <0.05).Symptom control time treatment group than the control group(P <0.05)[.Conclusion] Chaishao Xiaopi treating chronic atrophic gastritis with intestinal metaplasia significant clinical effect,should be popularized.