参芪膜肾颗粒辨证治疗特发性膜性肾病随机平行对照研究

TCM Treatment of Idiopathic Membranous Nephropathy Randomized Controlled Study

[目的]观察参芪膜肾颗粒辨证治疗特发性膜性肾病疗效。[方法]使用随机平行对照方法,将400例住院患者按随机数字表法分为两组。对照组200例洛汀新20mg/次,1次/d。潘生丁150mg/次,1次/d。胰激肽原酶360U/次,1次/d。高血脂加服立普妥10mg/次,1次/d。治疗组200例参芪膜肾颗粒。湿热较重加清热膜肾冲剂;肾气虚加固肾颗粒;肾阳虚加益肾颗粒;脾虚腹泻加补脾益肠丸;低蛋白血症或严重浮肿加黑料豆颗粒;严重水肿加黄芪注射液。连续治疗24周为1疗程。观测临床症状、生存率、肾功能(24h尿蛋白、血清肌酐)、血清白蛋白、不良反应。连续治疗1疗程,判定疗效。[结果]治疗组完全缓解86例,缓解83例,无效31例,总有效率84.50%,生存率93.00%。对照组完全缓解41例,缓解110例,无效49例,总有效率75.50%,生存率85.50%。治疗组疗效优于对照组(P<0.05)。[结论]参芪膜肾颗粒辨证治疗特发性膜性肾病,疗效较好,安全可靠,值得推广。

[Objective]Observe the traditional Chinese medicine program idiopathic membranous nephropathy effect.[Methods]Randomized controlled method,400 inpatients were randomly randomly divided into two groups.Control group of 200 patients with western medicine.Treatment group two hundred cases of Chinese medicine are brought about by Differential Treatment.Continuously for 24 weeks for a course of treatment,observation of clinical efficacy,adverse reactions.Continuous one course of treatment,to determine efficacy.[Results]The complete remission,86 cases to ease the 83 cases,31 cases ineffective,the total effective rate of 84.50%,93.00% survival rate.Control group,complete remission in 41 cases,to ease the 110 cases,49 cases ineffective,the total effective rate was 75.50%,the survival rate of 85.50%.The clinical efficacy of the treatment groupthan the control group(P< 0.05).[ Conclusion]TCM treatment of idiopathic membranous nephropathy,good effect,safe and reliable,worthy of promotion.