人参皂苷(GS)联合泼尼松治疗系统性红斑狼疮随机平行对照研究

Renshen Zaogan(GS) Combined with Prednisone Treatment of Systemic Lupus Erythematosus Random Parallel Control Study

[目的]观察人参皂苷(GS)联合泼尼松治疗系统性红斑狼疮疗效。[方法]使用随机平行对照方法,将60例住院患者按随机数字表法分为两组。对照组50例泼尼松,0.5～1mg(kg.d),60mg/d,连续3周;每周减l片(5mg),至30mg/d,维持1个月;重度期,≥1mg/(kg.d)+标准环磷酰胺冲击疗法(5mg/m2体表面积,1次/4周);轻中度期,5mg/(kg.d);稳定期,<15mg/d;红斑明显,抗疟药;关节痛明显,非甾体抗炎药,2次/d,口服。治疗组30例人参皂苷(GS),人参、茎叶、总皂苷,50mg/粒,50mg/次,2次/d,口服。西药治疗同对照组。连续治疗90d为1疗程。观测临床症状、疾病缓解时间、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组治愈10例,显效10例,有效5例,无效5例,总有效率83.33%。对照组治愈5例,显效15例,有效2例,无效8例,总有效率73.33%。治疗组疗效优于对照组(P<0.05)。SLE疾病活动指数(SLEDIA)评分比较治疗组改善优于对照组(P<0.05)。[结论]人参皂苷(GS)联合泼尼松治疗系统性红斑狼疮疗效显著,值得推广。

[Objective]To observe the renshen zaogan(GS) combined with prednisone treatment of systemic lupus erythematosus(sle).[Methods]Using random parallel control method,60 cases of hospitalized patients into two groups according to random number table method.Control group 50 prednisone,0.5~1mg(kg.d),3 weeks,60mg/day;A week l piece(5mg);When reduced to 30mg/day,maintain one month;Severe period,1mg/(kg.d)+or higher standard cyclophosphamide pulse therapy(5mg/m2 surface area,1/4 weeks);Mild-to-moderate,5mg/(kg.d);The status of <15mg/day;Obvious erythema,antimalarial drugs;Joint pain,non-steroidal anti-inflammatory drugs(nsaids),2 times/day,oral.Treatment group of 30 cases of renshen zaogan(GS),medicinal Renshen,Jingye,Zongzaogan,50mg/grain,50mg/times,2 times/day,oral sooner or later.Western medicine treatment with the control group.90d continuous treatment for 1 course of treatment.Observation of clinical symptoms,disease duration,adverse reactions.2 courses of treatment continuously,judge curative effect.[ Results]The treatment group,10 cases were complete response,10 cases had marked effect,5 cases effectively,5 no effect,the total effective rate was 83.33%.Control group complete response in 5 cases,15 cases were markedly effective,effective in 2 cases,8 no effect,the total effective rate was 73.33%.Treatment group curative effect is better than that of control group(P<0.05).SLEDIA score comparison treatment group improved better than the control group(P<0.05).[Conclusion]Renshen zaogan(GS) combined with prednisone treatment curative effect is distinct,systemic lupus erythematosus(sle) is worth promoting.