解郁化瘀汤治疗老年脑梗死后抑郁症随机平行对照研究

Randomized Controlled Study of Jieyu Huayu Decoction in the Treatment of Senile Depression after Cerebral Infarction

[目的]观察解郁化瘀汤治疗老年脑梗死后抑郁症疗效。[方法]使用随机平行对照方法,将40例住院及门诊患者按抽签法分为两组。对照组20例赛乐特,20mg/次,1次/d。治疗组20例柴胡解郁化瘀汤(柴胡、枳实、白芍、竹茹、涪陵、橘皮、香附、石菖蒲、郁金、白蕨藜各15g,合欢花30g,半夏、炙甘草、胆南星各10g,心烦加丹皮、栀子各10g;失眠症状加珍珠母、炒枣仁、柏子仁、夜交藤各30g;头晕加天麻20g,钩藤、菊花各30g)。1剂/d,水煎100mL,早晚口服。连续治疗56d为1疗程。观测临床症状、抑郁、不良反应。连续治疗1疗程,判定疗效。[结果]治疗组显效11例,有效8例,无效1例,总有效率95.00%。对照组显效9例,有效7例,无效4例,总有效率80.00%。治疗组疗效优于对照组(P<0.05)。SDS和HAMD评分治疗组优于对照组(P<0.05)。不良反应治疗组低于对照组(P<0.05)。[结论]解郁化瘀汤治疗老年脑梗死后抑郁症方面效果显著,值得推广。

[Objective]To observe the effect of Huayu Decoction in the treatment of senile depression after cerebral infarction.[Methods]Randomized controlled method was used,40 cases of outpatient and inpatient patients were divided into two groups by drawing lots.Control group,20 cases,Seroxat 20mg/times,1 times/d.They were gives continuous 56 days of treatment as a course of treatment.Treatment group,20 cases,Bupleurum stagnation decoction were elected(Chaihu,Zhishi,Baishao,Zhuru,Fuling,Jupi,Xiangfu,Shichangpu,Yujin,Baijueli each 15g,Hehuanhua 30g,Banxia,Zhigancao,Dannanxing 10g,if upset phenomenon,add 10g Danpi,Zhizi;any symptoms of insomnia,added Zhenzhumu,Chaozaoren,Boziren,Yejiaoteng30g;any dizziness,added Tianma 20g,Gouteng,Juhua30g).Decoction 100ml,oral used in the morning and at night,1 / d.The clinical symptoms,SDS(Self-rating Depression Scale),HAMD(Hamilton Depression Rating Scale),adverse reactions were observed.They were given continuous treatment of a course of treatment,and the efficacy was judged.[Results]In the treatment group,11 cases were markedly effective,8 cases effective,1 case not effective,the total effective rate was 95.00%.In the control group,9 cases were markedly effective,7 cases effective,4 cases not effective,the total effective rate was 80.00%.The effect of treatment group was better than that of the control group(P <0.05).SDS and HAMD scores were lower(P <0.05).Adverse rate was lower(P <0.05).[Conclusion]The effect of Jieyu Huayu Decoction is remarkable in the treatment of senile depression after cerebral infarction,it deserves to be promoted.