复方丹参滴丸治疗动脉粥样硬化随机平行对照研究

A Randomized Controlled Study on Compound Danshen Dripping Pills in Treating Atherosclerosis

[目的]观察复方丹参滴丸治疗动脉粥样硬化疗效。[方法]使用随机平行对照方法,将100例住院及门诊患者按随机数字表法分为两组。对照组50例阿托伐他汀钙,10mg/次,1次/d。治疗组50例复方丹参滴丸10丸/次,3次/d。连续治疗90d为1疗程。观测临床症状、低密度脂蛋白、甘油三酯、血清总胆固醇、高密度脂蛋白胆固醇、并氨酸转氨酶、不良反应。连续治疗1疗程,判定疗效。[结果]治疗组痊愈29例,显效10例,有效9例,无效2例,总有效率96.00%。对照组痊愈22例,显效13例,有效4例,无效11例,总有效率78.00%。治疗组疗效优于对照组(P<0.05)。指标变化治疗组优于对照组(P<0.05)。[结论]复方丹参滴丸治疗动脉粥样硬化方面效果显著,值得推广。

[Objective]To observe the curative effect of Compound Danshen Dripping Pills in treating atherosclerosis.[Methods]One hundred patients were randomly divided into two groups according to the random number table method.50 cases of control group were treated with atorvastatin calcium,10mg/time,1 time/d.Continuous treatment with 90d were a course of treatment.50 cases of treatment group were treated with ompound Danshen dripping pills 10 pills/time,3times/d.The clinical symptoms,low density lipoprotein,triglyceride,total cholesterol,high density lipoprotein cholesterol,alanine aminotransferase,adverse reaction were observed.After continuous treatment for a course of treatment,the curative effect was Determined[.Results] In the treatment group,29 cases were cured,markedly effective in 10 cases,effective in 9 cases,invalid in 2 cases,the total efficiency was 96.00%.In thecontrol group,22cases were cured,markedly effective in 13 cases,effective in 4 cases,invalid in 11 cases,the total efficiency was 78.00%.The efficacy of the treatment group was better than that in control group(P<0.05).Changes of index in treatment group were better than that in control group(P<0.05).[Conclusion]Effect of Compound Danshen Dripping Pills in treatment of atherosclerosis is significant,it is worthy of promotion.