辨证施治消化性溃疡随机平行对照研究

Evidence-based Medicine of Traditional Chinese Medicine Treatment of Peptic Ulcer Random Parallel Control Study

[目的]观察辨证施治消化性溃疡疗效。[方法]使用随机平行对照方法,将96例门诊患者按数字奇偶性方法随机分为两组。对照组48例雷贝拉唑10mg/次,2次/d;7d后,1次/d。治疗组48例辨证施治,肝胃气滞(蒲公英6g,甘草3g,陈皮8g,白芍12g);气滞血瘀,活血化瘀(丹参10g,红花8g,五灵脂12g,桃仁15g);脾胃虚寒(茯苓6g,桂枝10g,白术8g);胃阴亏虚(当归8g);湿热中阻(栀子10g,黄连3g)。1剂/d,水煎200mL,早晚口服。连续治疗10d为1疗程。观测临床症状、幽门螺旋杆菌转阴率、不良反应。连续治疗10疗程,判定疗效。[结果]治疗组痊愈39例,有效7例,无效2例,总有效率95.83%。对照组痊愈32例,有效6例,无效10例,总有效率79.16%。治疗组疗效优于对照组(P<0.05)。病情两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。幽门螺旋杆菌转阴率两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。[结论]辨证施治消化性溃疡效果显著,值得推广。

[Objective]To observe the curative effect of traditional Chinese medicine treatment of peptic ulcer.[Methods]Using random parallel control method,96 cases of clinic patients according to the press numeric parity method randomly divided into two groups.The control group of 48 cases of conventional western medicine treatment,rabeprazole azole 10 mg/time,2 times/d.After 7d,1/d.Observation group 48 cases of evidence-based medicine,liver and stomach(Pugongying 6g,Gancao3g,Chenpi 8g,Baishao12g);And qi stagnation and blood stasis,promoting blood circulation to remove blood stasis(Danshen10g,Honghua 8g,Wulingzhi 12g,Taoren 15g);Spleen and stomach cold(Fuling 6g,Guizhi10g,Baishu 8g);stomach Yin deficiency,Yin nourishing the stomach,(Dangui 8g);In the wet and heat resistance(Zhizi 10g,Huanglian 3g).1/d,and 200 mL water,oral sooner or later.Continuous treatment of 10d for 1 course of treatment.Observation of clinical symptoms.pylori turn rate and adverse reactions.Treatment of 10 consecutive period of treatment,judge curative effect[.Results]Observation group 39 cases were cured,7cases effectively,2 had no effect,the total effective rate was 95.83%.Control group 32 cases cured,6 cases,10cases of invalid,the total effective rate was 79.16%.The observation group curative effect is better than that of control group(P<0.05).The improvement in the two groups were improved(P<0.05),the treatment group is better than that of control group(P<0.05).Helicobacter pylori overcast rate of two groups were improved(P<0.05),the treatment group is better than that of control group(P<0.05).[Conclusion]TCM syndrome differentiation treatment of peptic ulcer effect is remarkable,is worth promoting.