丹参黄芪注射液合用治疗冠心病心绞痛随机平行对照研究

Salvia Miltiorrhiza Astragalus Membranaceus Injection Treatment of Coronary Heart Disease Angina Pectoris Random Parallel Control Study

[目的]观察丹参黄芪注射液合用治疗冠心病心绞痛疗效。[方法]使用随机平行对照方法,将150例住院患者按就诊顺序编号随机分为3组。I组50例黄芪注射液20mL+5%葡萄糖溶液250mL或0.9%生理盐水250mL,1次/d。II组50例丹参注射液20mL+5%葡萄糖溶液250mL或0.9%生理盐水250mL,1次/d。III组50例丹参注射液20mL+5%葡萄糖溶液250mL或0.9%生理盐水250mL,1次/d;黄芪注射液20mL+5%葡萄糖溶液250mL或0.9%生理盐水250mL,1次/d。连续治疗10d为1疗程。观测临床症状、心绞痛指标、不良反应。治疗1疗程,判定疗效。[结果]III组显效46例,有效2例,无效4例,总有效率96.00%。II组显效18例,有效22例,无效10例,总有效率80.00%。I组显效18例,有效20例,无效12例,总有效率76.00%。三组疗效差异具有统计学意义(P<0.05)。三组心绞痛指标均有改善(P<0.05),III组改善优于II、I(P<0.05)。[结论]丹参黄芪注射液合用治疗冠心病心绞痛的效果显著,优于单一用药,值得推广使用。

[Objective]To observe salvia miltiorrhiza astragalus membranaceus injection treatment of coronary heart disease angina pectoris curative effect.[Methods]Using random parallel control method,150cases of hospitalized patients in hospital order method were randomly divided into three groups. I group of 50cases of 20 ml 250 ml of astragalus membranaceus injection+5% glucose solution or 0.9% saline 250ml,1/d. II group of 50 cases of 20 ml 250 ml of salvia miltiorrhiza injection+5% glucose solution or 0.9% saline 250ml,1/d.III group of 50 cases of 20 ml 250 ml of salvia miltiorrhiza injection+5% glucose solution or 0.9% saline 250ml,1/d;20 ml 250 ml of astragalus membranaceus injection + 5% glucose solution or 0.9% saline 250 ml,1/d.Continuous treatment of 10d to 1 course of treatment. Observation of clinical symptoms,angina pectoris,adverse reactions. Continuous treatment 1 treatment course,judge curative effect.[Results]III group 46 cases were markedly improved,effective in 2 cases,4 cases were invalid,the total effective rate was 96.00%. II group of18 cases were markedly effective,effective 22 cases,10 cases were invalid,the total effective rate was 80.00%.I group of 18 cases were markedly effective,effective 20 cases,12 cases ineffective,the total effective rate was76.00%. Three groups of efficacy differences statistically significant(P<0.05). Three groups of angina pectoris index were improved(P<0.05),group is better than that of II,I(P<0.05). Salvia miltiorrhiza astragalus membranaceus injection.[Conclusion]The effect of the treatment of coronary heart disease angina pectoris,significantly better than the single drug,used to be promoted.