温阳补气汤联合促红细胞生成素治疗慢性肾功能不全贫血随机平行对照研究

WenyangBuqi Decoction Combined with Erythropoietin Treatment of Anemia in Chronic Renal Insufficiency Randomized Parallel Group Study

[目的]观察温阳补气汤联合促红细胞生成素治疗慢性肾功能不全贫血疗效。[方法]使用随机平行对照方法,将80例门诊患者按抽签法随机分为两组。对照组40例注射促红细胞生成素EPO,开始剂量每次50u/kg,3次/周。治疗组40例温阳补气汤(党参、鹿角胶、菟丝子各15g,白术、茯苓、当归、何首乌各10g,黄芪30g);1剂/d,水煎300mL,早晚口服。西药治疗同对照组。连续治疗6周为1疗程。观测临床症状、血红蛋白(Hb)、尿素氮(BUN)、血肌酐(Scr)、血清总蛋白(TP)、红细胞压积(HCT)、不良反应。连续治疗2疗程,判定疗效。[结果]血生化指标两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05);EPO用量治疗组明显少于对照组(P<0.05)。[结论]温阳补气汤联合促红细胞生成素治疗慢性肾功能不全贫血效果显著,值得推广使用。

[Objective] Observe WangyangBuqi Decoction Combined Treatment of erythropoietin treatment of anemia of chronic renal insufficiency. [Methods] Using randomized controlled method, 80 outpatients were randomly divided into two groups according to. The control group of 40 patients injected erythropoietin EPO, a starting dose of each 50u/kg, 3 times / week. Treatment group 40 cases WangyangBuqi soup( Dangshen, Lujiaojiao, Tusizieach 15g, Baishu, Fuling, Danggui, Heshouwu each 10g, Huangqi 30g); 1does/ d, decoction 300mL, sooner or later orally. Western medicine with the control group. Continuous treatment for 6 weeks as a course of treatment. Observations of hemoglobin(Hb), blood urea nitrogen(BUN), serum creatinine(Scr), serum total protein(TP), hematocrit(HCT), adverse reactions. 2 courses of continuous treatment, to determine efficacy. [Results] blood biochemical indicators improved in both groups(P<0.05), the treatment group than the control group improved(P<0.05); EPO dosage treatment group was significantly less than the control group(P<0.05). [Conclusion] WangyangBuqi soup Combined erythropoietin treatment of anemia of chronic renal insufficiency effect is significant and should be introduced.