蒲地蓝联合阿奇霉素治疗小儿急性扁桃体炎随机平行对照研究

Randomized Parallel Controlled Study of the Combination of Pudilan Oral Lliquid and Azithromycin in the Treatment of Acute Tonsillitis in Children

[目的]观察蒲地蓝联合阿奇霉素治疗小儿急性扁桃体炎疗效。[方法]使用随机平行对照方法,将80例住院患者按病志号抽签分为两组。对照组40例阿奇霉素,10mg/kg·d^(-1)+5%葡萄糖500mL,静滴,时间>1h,静滴3d停药4d。治疗组40例蒲地蓝,10mL/次,2次/d;阿奇霉素治疗同对照组。连续治疗7d为1疗程。观测临床表现、体温恢复正常时间、咽部肿大消失时间、咽部渗出物消失时间、白细胞、不良反应。治疗1疗程(7d),判定疗效。[结果]治疗组痊愈25例,显效10例,有效4例,无效1例,总有效率97.50%;对照组痊愈19例,显效9例,有效6例,无效6例,总有效率85.00%;治疗组疗效优于对照组(P<0.05)。体温恢复正常时间、咽部肿大消失时间治疗组短于对照组(P<0.05)。白细胞两组均有降低(P<0.01),治疗组降低多于对照组(P<0.01)。[结论]蒲地蓝联合阿奇霉素治疗小儿急性扁桃体炎,疗效满意,无严重不良反应,值得推广。

[Objective] To observe the curative effect of Pudilan oral liquid combined with azithromycin on children with acute tonsillitis. [Methods] Using random parallel control method, 80 inpatients were divided into two groups according to the number of disease records. 40 cases in control group were treated with azithromycin, 10 mg/kg·d-1 + 5% glucose injection 500 mL, intravenous drip, time>1 h, intravenous drip for 3 days discontinued for 4 day. In treatment group, 40 cases were treated with 10 mL/time, 2 times/d, and azithromycin treatment group. Continuous treatment of 7 d for 1 courses. The clinical manifestations, recovery time of body temperature, disappearance time of pharyngeal swelling, white blood cell count and adverse reactions were observed. Treatment of 1 courses(7 d), determine the curative effect. [Results] In the treatment group, 25 cases were cured, 10 cases were markedly effective, 4 cases were effective, 1 case was ineffective,the total effective rate was 97.50%;in the control group, 19 cases were cured, 9 cases were markedly effective,6 cases were effective, 6 cases were ineffective, the total effective rate was 85.00%;the curative effect of the treatment group was better than that of the control group(P<0.05). The recovery time of body temperature and the time of disappearance of pharyngeal swelling were shorter in the treatment group than in the control group(P<0.05). The two groups of white blood cell count decreased(P<0.01), and the treatment group decreased more than the control group(P<0.01). [Conclusion] Pudilan oral liquid combined with azithromycin in the treatment of children with acute tonsillitis, the efficacy is satisfactory, no serious adverse reactions, is worth promoting.