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加味通窍活血汤联合西药治疗缺血性脑卒中(气虚血瘀)随机平行对照研究 被引量:5

Jiawei Tongqiao Huoxue Decoction(加味通窍活血汤) combined with Western Medicine in the Treatment of Ischemic Stroke(Qixu Xueyu/气虚血瘀) Randomized Parallel Controlled Study
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摘要 [目的]观察加味通窍活血汤联合西药治疗缺血性脑卒中(气虚血瘀)疗效。[方法]使用随机平行对照方法,将84住院患者按病志号抽签方法随机分为两组。对照组42例阿司匹林,100mg/次,1次/d,饭前口服;阿托伐他汀,20mg/次,1次/d;氯吡格雷,75mg/次,1次/d。治疗组42例加味通窍活血汤(黄芪30g,川芎、大枣、老葱、当归各15g,赤芍、桃仁、丹参各12g,红花、生姜各9g,麝香0.15g,黄酒150g),水煎200mL,早晚分服用(昏迷者鼻饲);西药治疗同对照组。连续治疗14d为1疗程。观测临床表现、纤维蛋白原(FG)、血浆黏度(PRV)、血脂指标、不良反应。治疗1疗程(14d),判定疗效。[结果]纤维蛋白原、血浆黏度两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。LDL两组均有改善(P<0.01),治疗组改善优于对照组(P<0.05),TC、TG治疗组有改善(P<0.01),对照组无显著变化(P>0.05)。[结论]加味通窍活血汤联合西药治疗缺血性脑卒中(气虚血瘀),疗效满意,无严重不良反应,值得推广。 [Objective]To observe the curative effect of Jiawei Tongqiao Huoxue decoction combined with western medicine on ischemic stroke(Qixu Xueyu).[Method]84 hospitalized patients were randomly divided into two groups by drawing lots according to the disease sign by random parallel control method.The control group consisted of 42 cases of aspirin,100 mg/time,once a day,oral before meals;atorvastatin,20 mg/time,once a day;clopidogrel,75 mg/time,once a day.In the treatment group,42 cases were treated with modified Tongqiao Huoxue decoction(Huangqi 30 g,Chuanxiong,Dazao,Laocong,Danggui each 15 g,Chishao,Taoren,Danshen each 12 g,Honghua,Shengjiang each 9 g,Shexiang 0.15 g,Huangjiu 150 g),decocted with water 200 mL,taken in the morning and evening(nasal feeding for comatose patients);western medicine treatment was the same as the control group.Continuous treatment for 14 days is a course of treatment.Clinical manifestations,fibrinogen(FG),plasma viscosity(PRV),lipid index and adverse reactions were observed.One course of treatment(14 days)was used to determine the curative effect.[Results]Fibrinogen and plasma viscosity were improved in both groups(P<0.01).The improvement in treatment group was better than that in control group(P<0.01).LDL was improved in both groups(P<0.01).The improvement in treatment group was better than that in control group(P<0.05).TC and TG groups were improved(P<0.01).There was no significant change in control group(P>0.05).[Conclusion]Jiawei Tongqiao Huoxue decoction combined with western medicine in the treatment of ischemic stroke(Qixu Xueyu)has satisfactory curative effect and no serious adverse reactions,which is worthy of promotion.
作者 宋晓明 SONG Xiaoming(Department of Traditional Chinese Medicine,Mianchi County Hospital of Traditional Chinese Medicine,Mianchi 472400,Henan,China)
出处 《实用中医内科杂志》 2019年第1期50-53,共4页 Journal of Practical Traditional Chinese Internal Medicine
关键词 缺血性脑卒中 中风 气虚血瘀 加味通窍活血汤 阿司匹林 托伐他汀钙 氯吡格雷 FG PRV LDL TC TG 中药复方 随机平行对照研究 ischemic stroke stroke Qixu Xueyu Jiawei Tongqiao Huoxue decoction(加味通窍活血汤) aspirin tovastatin calcium clopidogrel FG PRV LDL TC TG traditional Chinese medicine compound randomized parallel controlled Study
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