肠道菌群及针刺调节与动脉粥样硬化防治

Intestinal Flora and Acupuncture Regulation and Prevention and Treatment of Atherosclerosis

肠道菌群存在于肠道,多种微生物拮抗共生、动态平衡,一旦平衡破坏,可引起宿主发生多种疾病。脑-肠轴理论提出肠道菌群与焦虑、抑郁等情绪障碍也有关系。动脉粥样硬化是冠心病、脑卒中等多种心脑血管病变的病理基础,与肠道菌群组成改变及功能失调之间可能存在一定联系。肠道菌群同黏膜免疫相互作用,代谢产物氧化三甲胺可能对AS形成有影响,短链脂肪酸可影响危险因素的出现,增加AS发生。动脉粥样硬化可归属"胸痹""真心痛""血脉病""痰饮""中风"等范畴,为本虚标实,本虚为气、血、阴、阳虚,可累及心、肝、脾、肾;气滞、寒凝、痰阻、血瘀为标。肠道菌群与宿主生理相关、病理相互影响,与中医学天人相应、整体观理念一致,与阴阳学说、脾胃有异曲同工之处。针刺防治AS着眼于整体调节,对肠道菌群也有调节作用,辨证取穴,从痰、瘀、毒论治,整体调节脏腑功能,通过对大脑、肠道菌群、骨髓的整体调节,可能是AS防治效应机制。针灸影响肠道菌群数量与结构,恢复宿主肠道内环境动态平衡,是AS防治重要着眼点。未来高通量测序、高效液相色谱、气相色谱等为研究肠道菌群与针刺治疗动脉粥样硬化关系提供了技术保证。

Intestinal flora exists in the intestine,and various microorganisms antagonize symbiosis and dynamic balance.Once the balance is destroyed,various diseases may occur in the host.The brain-gut axis theory suggests that the intestinal flora is also associated with emotional disorders such as anxiety and depression.Atherosclerosis is the pathological basis of various cardiovascular and cerebrovascular diseases in coronary heart disease and stroke,and may be related to the changes in intestinal flora composition and dysfunction.Intestinal flora interacts with mucosal immune system,and the metabolite oxidized trimethylamine may affect the formation of AS.Short-chain fatty acids may affect the occurrence of risk factors and increase the incidence of AS.Atherosclerosis can be attributed to the categories of'chest','true heart pain','blood vein disease','sip','stroke',etc.,which is a virtual standard,which is qi,blood,yin and yang,and can involve the heart.Liver,spleen,kidney;qi stagnation,cold coagulation,phlegm obstruction,blood stasis as the standard.The intestinal flora is related to the host’s physiology and pathology.It is consistent with the traditional Chinese medicine and the overall concept,and has the same symmetry with the yin and yang theory and the spleen and stomach.Acupuncture prevention and treatment AS focuses on the overall regulation,and also has a regulating effect on the intestinal flora.The syndrome differentiation and acupoints are treated from sputum,sputum and poison,and the overall function of the viscera is regulated.Through the overall regulation of the brain,intestinal flora and bone marrow,May be the AS prevention effect mechanism.Acupuncture affects the number and structure of intestinal flora and restores the dynamic balance of the environment in the host intestinal tract.It is an important point of attention for AS prevention and treatment.Future high-throughput sequencing,high performance liquid chromatography,and gas chromatography provide technical guarantees for studying the relationship between intestinal flora and acupuncture for atherosclerosis.