膈下逐瘀汤联合消炎痛栓治疗原发性痛经(气滞血瘀)临床观察

Randomized Parallel Controlled Study of Gexia Zhuyu Decoction Combined with Indomethacin Suppository in Treatment of Primary Dysmenorrhea(Qi Stagnation and Blood Stasis)

[目的]观察膈下逐瘀汤联合消炎痛栓治疗原发性痛经(气滞血瘀)疗效。[方法]将120例门诊患者按就诊顺序号方法随机分为两组。对照组60例消炎痛栓,直肠给药,轻轻塞入肛门约2cm处,1枚/次,1次/d,月经来潮第1天开始使用。治疗组60例膈下逐瘀汤[乌药、没药、川芎、红花、枳壳、蒲黄(包煎)各6g,桃仁、延胡索、五灵脂、当归、赤芍各10g,制香附、炙甘草各9g],水煎300mL,经期前3d开始服用,2次/d,早晚温服,服用至月经结束;消炎痛栓治疗同对照组。连续治疗1个月经周期为1疗程。观测临床表现、VAS评分、不良反应。连续治疗3疗程(3个月经周期),判定疗效。[结果]治疗组显效31例,有效37例,无效7例,总有效率90. 67%;对照组显效20例,有效36例,无效19例,总有效率74. 67%;治疗组疗效优于对照组(P <0. 05)。VAS评分两组均有改善(P <0. 01),治疗组改善优于对照组(P <0. 01)。[结论]膈下逐瘀汤联合消炎痛栓治疗原发性痛经(气滞血瘀),疗效满意,无严重不良反应,值得推广。

[Objective]To observe the curative effect of Gexia Zhuyu Decoction combined with Indomethacin Suppository on primary dysmenorrhea(Qi stagnation and blood stasis).[Method]A total of 120 outpatients were randomly divided into two groups according to the order number of visits by randomized parallel control method.The control group consisted of 60 cases and were treated withIndomethacin Suppository by rectal administration,gently inserting into the anus about 2 cm,1 piece per time,1 time per day,starting from the menstrual first day.The patients in the control group took Indomethacin Suppository for 2 to 3 days before menstruation and dysmenorrhea.In the treatment group,60 cases were treated with Gexia Zhuyu decoction[Wuyao(Lindera aggregata 6 g),Moyao(Commiphora myrrha 6 g),Chuanxiong(Ligusticum chuanxiong hort 6 g),Honghua(Carthamus tinctorius 6 g),Zhiqiao(Citrus aurantium 6 g),Puhuang(Typha angustifolia6 g),Taoren(Prunus persica 10 g),Yanhusuo(Corydalis yanhusuo 10 g),Wulingzhi(Faeces Trogopterpri10 g),Danggui(Angelica sinensis 10 g),Chishao(Paeonia lactiflora 10 g),Zhixiangfu(Cyperus rotundus9 g),Gancao(licorice 9 g)]were decocted with water for 300 m L.They were taken three days before menstruation,twice a day,taking in the morning and evening,and finished untile menstruation.Indomethacin Suppository treatment was the same as the control group.Continuous treatment of one menstrual cycle was a course of treatment.Clinical manifestations,VAS scores and adverse reactions were observed.After continuous treatment for 3 courses(3 menstrual cycles),we determined the efficacy.[Result]Thirty-one cases were markedly effective in the treatment group,37 cases were effective,7 cases were ineffective,and the total effective rate was 90.67%.Twenty cases were markedly effective in the control group,36 cases were effective,19 cases were ineffective and the total effective rate was 74.67%.The curative effect of the treatment group was better than that of the control group(P<0.05).VAS scores were improved in both groups(P<0.01),and the improvement in treatment group was better than that in the control group(P<0.01).[Conclusion]Gexia Zhuyu Decoction combined with Indomethacin Suppository in the treatment of primary dysmenorrhea(Qi stagnation and blood stasis)has satisfactory curative effect and no serious adverse reactions,which is worthy of promotion.