加味柴胡疏肝散治疗肝胃不和型功能性消化不良临床观察

Clinical Observation of Modified Chaihu Shugan Powder in Treatment of Functional Dyspepsia of Liver-Stomach Disharmony

[目的]观察加味柴胡疏肝散治疗肝胃不和型功能性消化不良疗效。[方法]将60例住院及门诊患者按诊顺序号随机分两组。对照组30例奥美拉唑,20mg/次,2次/d,早晚餐前半小时服用;多潘立酮,10mg/次,3次/d,饭前半小时。治疗组30例加味柴胡疏肝散;腹胀明显加枳壳改为20g;烧心、反酸加乌贼骨20g;纳差加炒莱菔子、焦山楂各15g;胃痛明显加延胡索15g);1剂/d,水煎300mL,早晚各150mL。治疗1疗程(1个月)。观测临床表现、中医证候积分、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈20例,显效4例,有效2例,无效4例,总有效率86. 70%;对照组痊愈15例,显效2例,有效3例,无效10例,总有效率66. 70%;治疗组疗效优于对照组(P <0. 05)。中医证候积分两组均有明显降低(P <0. 01),治疗组降低优于对照组(P <0. 01)。[结论]加味柴胡疏肝散治疗肝胃不和型功能性消化不良,疗效满意,无严重不良反应,值得推广。

[Objective]To observe the therapeutic effect of Modified Chaihu Shugan Powder on functional dyspepsia of disharmony between liver and stomach.[Method]Sixty inpatients and outpatients were randomly divided into two groups according to the order of diagnosis.In the control group,30 cases of omeprazole,20 mg/time,2 times/day,half an hour before breakfast and dinner,domperidone,10 mg/time,3 times/day,half an hour before meals,1 dose/d,150 mL in the morning and 150 mL in the evening.In the treatment group,30 cases were treated with Modified Chaihu Shugan Powder.For abdominal distention,Zhiqiao20 g was added.For acid reflux,Wuzeigu 20 g was added.For poor indigestion,Laifuzi 15 g and Shanzha15 g were added.For stomach pain,Yanhusuo 15 g was added.The clinical manifestations,TCM syndrome scores,adverse reactions were observed.And after one course of treatment,the efficacy was determined.[Result]In the treatment group,20 cases were cured,4 cases markedly effective,2 cases effective and 4 cases ineffective and the total effective rate was 86.70%.In the control group,15 cases were cured,2 cases markedly effective,3 cases effective and 10 cases ineffective and the total effective rate was 66.70%.The curative effect of the treatment group was better than that of the control group(P<0.05).The scores of TCM syndromes in both groups were significantly decreased(P<0.01),and the decrease in treatment group was better than that in the control group(P<0.01).[Conclusion]Modified Chaihu Shugan Powder is effective in treating functional dyspepsia of disharmony between liver and stomach,and has no serious adverse reactions.It is worthy of popularizing.