魔芋葡甘聚糖对动脉粥样硬化家兔血清一氧化氮、血浆内皮素和脂质过氧化物的影响

Effects of glucomanan on nitric oxide, endothelin and lipid peroxidation in atheroscierotic rabbits

目的 :观察魔芋葡甘聚糖预防用药对动脉粥样硬化 (AS)家兔血清一氧化氮 (NO) ,血浆内皮素(ET)、脂质过氧化物 (MDA)和超氧化物歧化酶(SOD)的影响。方法 :采用高胆固醇饲料喂饲另加牛血清白蛋白一次注射方法 ,建立家兔AS模型 ,随机分为对照组 (n =8) ,模型组 (n =8)和魔芋葡甘聚糖用药组 (n =8) ,各组在实验第 8周取血清标本测定血清NO ,血浆ET、MDA和SOD。结果 :与模型组比较 ,魔芋葡甘聚糖预防用药 8周 ,能提高NO和SOD活性 (P <0 .0 1) ,降低ET和MDA含量 (P <0 .0 1)。结论 :魔芋葡甘聚糖具有抗氧化。

AIM: To observe the effects of glucomanan on nitric oxide (NO), endothelin (ET), lipid peroxide and superoxide dismutase (SOD) in experimental atherosclerotic rabbits. METHODS: An atherosclerotic rabbit model was established by feeding high cholesterol diet supplemented by bovine serum albumin injection bolus. The rabbits were randomly divided into the control, model, and glucomanan treatment group. Blood samples were collected 8 weeks after the treatment. RESULTS: After glucomanan administration for 8 wk, the NO and activity of SOD increased in comparison with model group (P< 0.01 ), while MDA and ET decreased (P< 0.01 ). CONCLUSION: Glucomanan has the effects of antioxidation, preserving endothelial function, and maintaining the balance of NO/ET.