人工肝支持系统治疗重型肝炎临床疗效评价

Evaluation of the effect of artificial liver support system on severe hepatitis

目的 :评估人工肝支持系统 (ALSS)治疗重型肝炎的临床疗效。方法 :治疗组 32例和对照组 38例 ,两组均按重型肝炎常规综合治疗 ,治疗组同时给予ALSS治疗。结果 :ALSS治疗后 ,重型肝炎患者症状明显改善 ,肝功能等明显好转。治疗组好转率4 6 .9% ,对照组为 2 3.2 % ;两组差异有显著性 (P <0 .0 5 )。重型肝炎早、中、晚期应用ALSS治疗 ,好转率分别为 80 .0 %、5 0 .0 %和 10 %。结论 :ALSS治疗重型肝炎疗效肯定 ,宜在早。

AIM: To evaluate the therapeutic effect of artificial liver support system (ALSS) in the treatment of severe hepatitis. METHODS: Seventy patients with severe hepatitis were enrolled in two groups: treatment group (n=32) given ALSS combined with a routine treatment, and control group (n=38) only given the routine treatment. RESULTS: The liver functions of patients in treatment group were significantly improved after ALSS therapy. The total clinical efficacy rates in treatment group and control group were 46.9 % and 23.2 %, respectively (P< 0.05 ). The efficacy rates of patients receiving ALSS therapy in early, middle and late stage were 80.0 %, 50.0 % and 10.0% respectively. CONCLUSION: ALSS is effective in treatment of severe hepatitis, especially in early and middle stage.