摘要
目的 :建立了一种HPLC方法用于硝苯地平片的含量测定。方法 :采用ODS柱 ,以甲醇 水 (6 0 4 0 )为流动相 ,流速为 0 .8ml·min- 1,检测波长为 2 35nm。结果 :硝苯地平的线性范围为 0 .0 2 0~ 0 .2 0 0g·L- 1;高、中、低 3个浓度的平均回收率分别为99 .6 % ,98.9% ,10 0 .4 % ;RSD分别为 0 .4 2 % ,0 .5 4% ,0 .35 % (n =5 )。结论 :本法专属性强 ,灵敏度高 ,结果准确 。
AIM: To establish a HPLC method to determine nifedopine the content and uniformity of nifedopine tablet. METHODS: HPLC condition was set as ODS column, flow phase: methanol water (6040), flow rate: 0.8 ml·min -1 , and detection wavelength: 235 nm. RESULTS: The nifedopine linear range was 0.020-0.200 g·L -1 in this method. The average recovery rates were 99.6%, 98.9%, and 100.4% in high, normal and low concentrations, respectively. The corresponding values of RSD were 0.42%, 0.54% and 0.35% (n=5). CONCLUSION: This HPLC method shows a high specificity and sensitivity, and is accurate, simple and rapid in performance.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2002年第6期555-556,共2页
Chinese Journal of Clinical Pharmacology and Therapeutics