坤泰胶囊与雌孕激素序贯疗法在围绝经期综合征治疗中的疗效比较

Comparison of the Effect of Kuntai Capsule and estrogen Progesterone Sequencing Therapy on Menopausal Syndrome

目的旨在探究坤泰胶囊在MPS治疗中的应用效果,并与雌孕激素序贯疗法的疗效进行比较。方法选择2014年7月—2016年9月到该科就诊的67例MPS患者,按随机数表法将其分成两组,对照组34例患者应用雌孕激素序贯疗法,观察组33例患者应用坤泰胶囊,比较两组治疗有效性及安全性。结果 3个月后,观察组KI总评分为(9.91±1.04)分,对照组为(10.13±0.75)分,两组KI评分与治疗前相比明显降低(P<0.05),但组间差异无统计学意义(P>0.05);观察组总有效率为75.76%,对照组为82.35%,组间差异无统计学意义(P>0.05);与治疗前相比,两组FSH、E2值均有明显的降低,且观察组E2值明显低于对照组;观察组药物不良反应发生率为3.03%,对照组为11.76%。结论在围绝经期综合征治疗中,坤泰胶囊与雌孕激素序贯疗法疗效相当,但坤泰胶囊能够显著控制患者体内性激素水平,且其安全性较高。

Objective To compare the efficacy of Kuntai capsule and estrogen progesterone sequential therapy on menopausal syndrome. Methods 67 patients from July 2014 to September 2016 were randomly divided into control group(n=34,estrogen and progesterone sequential therapy),and observation group(n=33,Kuntai capsule) Compare the effectaeness and afety of the two groups. Results Three months later, the observation group KI was divided into(9.91±1.04)points and the control group(10.13±0.75)points,The KI score of the two groups was significantly lower than before treatment(P<0.05), but there was no statistically significant difference between the groups(P>0.05).The total effective rate of observation group was 75.76%, while the control group was 82.35 %. There was no significant difference between the groups(P>0.05).Both FSH and E2 values were significantly lower than before treatment, and the E2 values in the observation group were significantly lower than those in the control group. The incidence of adverse drug reactions was 3.03%in the observation group and 11.76% in the control group Conclusion The Kuntai capsule can effectively control the body's sex hormone levels,and has high safety.