柯萨奇B组病毒与小儿急性短暂性跛行发病关系的分析

Analysis of the Relationship between Coxsackie B Virus and Acute Transient Claudication in Children

目的分析柯萨奇B组病毒与小儿急性短暂性跛行发病关系。方法选取2015年12月—2018年5月收治的小儿急性短暂性跛行患儿100例、上呼吸道感染患儿100例以及健康儿童100名建立急性短暂性跛行组、上呼吸道感染组以及健康对照组展开研究,对各组研究对象血清行柯萨奇B组病毒1~6型(CVB1~CVB6)的Ig M检测。结果急性短暂性跛行组的病毒阳性检出率50.0%,该组检出柯萨奇B组病毒以B1型为主(37.0%),其次为B4型(16.0%),其中检出双重阳性病例占34.0%(17/50);上呼吸道感染组病毒阳性检出率26.0%,该组检出柯萨奇B组病毒以B1型为主(14.0%),其次为B4型(11.0%),其中检出双重阳性病例占38.5%(10/26);健康对照组的病毒阳性检出率12.0%,该组检出柯萨奇B组病毒以B1型为主(6.0%),其次为B4型(4.0%)。3组病毒阳性检出率对比上急性跛行组显著高于其他两组,对比差异有统计学意义(P<0.05)。结论柯萨奇B组病毒的感染在小儿急性短暂性跛行的发病中存在密切的相关性,其可能是导致小儿发病的一个感染因素,临床上通过CVB分型检测特异性Ig M抗体,对于该病具重要的诊断价值。

Objective To analyze the relationship between Coxsackie B virus and acute transient claudication in children. Methods 100 acute transient claudication Children,100 upper respiratory tract infection Children and 100 healthy children from December 2015 to Mary 2018 were selected to establish acute transient claudication group, upper respiratory tract infection Children and healthy control group. The serum levels of Coxsackie B virus type 1(CVB1) and CVB6(CVB6) were detected in each group. Results The positive rate of virus in acute transient claudication group was 50.0%.Coxsackie B virus was detected mainly in B1(37.0%), followed by B4 type(16.0%). The detection rate of double positive cases was 34.0%(17/50), and the positive rate of virus positive in the upper respiratory tract infection group was 26.0%.The group B virus was mainly B1 type(14.0%), followed by type B4(11.0%), of which double positive cases accounted for 38.5%(10/26), and the positive rate of virus positive in the healthy control group was 12.0%, and this group detected the Coxsackie B group virus with B1 Type 1(6.0%), followed by B4(4.0%), and.3 positive rate were significantly higher than those of the other two groups in the acute limp group,the difference was statistically significant(P<0.05) Conclusion Coxsackie B virus infection is closely related to acute transient claudication in children, which may be an infection factor leading to the onset of infantile disease. The specific Ig M antibody is detected by CVB typing in clinic. It has important diagnostic value for the disease.