高通量透析对尿毒症血液透析患者不宁腿综合征的疗效

Effect of High-flux Dialysis on Restless Legs Syndrome in Hemodialysis Patients with Uremia

目的探究高通量透析对尿毒症血液透析患者不宁腿综合征的疗效。方法选取该院自2015年3月—2018年3月收治的110例维持性血液透析尿毒症不宁腿综合征患者,随机分成两组,对照组55例低通量透析,研究组55例高通量透析,比较两组血清学指标及生活质量。结果研究组甲状旁腺激素(9.03±0.56)nmol/L、β2-微球蛋白(2.76±1.04)μg/L、血清肌酐(52.54±4.30)μmol/L以及血清尿素氮均比对照组低,差异有统计学意义(P<0.05),且研究组生活质量比对照组好,差异有统计学意义(P<0.05)。结论在尿毒症血液透析不宁腿综合征运用高通量透析可减少体内中、大分子毒素,对生活质量的改善有一定作用,在临床治疗中具有一定应用价值。

Objective To investigate the effect of high-flux dialysis on restless legs syndrome in hemodialysis patients with uremia. Methods One hundred and ten patients with maintenance hemodialysis uremia and restless legs syndrome admitted to our hospital from March 2015 to March 2018 were randomly divided into two groups. 55 patients in the control group underwent low-flux dialysis, and 55 patients in the study group. High-throughput dialysis, comparing serological indicators and quality of life between the two groups. Results Parathyroid hormone(9.03±0.56) nmol/L, β2-microglobulin(2.76±1.04) μg/L, serum creatinine(52.54±4.30) μmol/L and serum urea nitrogen were lower in the study group than in the control group,the difference was statistically significant(P<0.05), and the quality of life of the study group was better than the control group, the difference was statistically significant(P<0.05). Conclusion High-flux dialysis in uremic hemodialysis restless legs syndrome can reduce the macrotoxins in the body and has a certain effect on the improvement of quality of life. It has certain application value in clinical treatment.