抗环瓜氨酸肽抗体与类风湿因子联合检测在类风湿性关节炎中的诊断价值

Diagnostic Value of Combined Detection of Anti-cyclic Citrullinated Peptide Antibody and Rheumatoid Factor in Rheumatoid Arthritis

目的对于在类风湿性关节炎诊断的过程中使用抗环瓜氨酸肽抗体与类风湿因子联合检测的应用价值进行探讨分析。方法从该市医院中挑选出90例病况大致相同的类风湿性关节炎患者进行一系列的临床实验,患者就诊时间为在2016年5月—2018年11月,将这90例类风湿性关节炎患者分为两组,每组45例患者。对其中的一组类风湿性关节炎患者使用类风湿因子检测法进行检测,此为对照组;另一组患者使用抗环瓜氨酸肽抗体与类风湿因子联合检测进行检测,此为实验组。然后对这两组类风湿性关节炎患者的检测结果进行比较。结果实验组患者中有42例患者检测结果呈阳性,阳性检出率为93.3%;对照组患者中有32例患者检测结果呈阳性,阳性检出率为83.6%;实验组患者的阳性检出率明显高于对照组患者的阳性检出率,两者之间的差异有统计学意义(P<0.05)。结论在类风湿性关节炎诊断的过程中使用抗环瓜氨酸肽抗体与类风湿因子联合检测的阳性检出率较高,具有很高的诊断价值,值得进一步推广。

Objective To evaluate the value of combined detection of anti-cyclic citrullinated peptide antibody and rheumatoid factor in the diagnosis of rheumatoid arthritis.Methods Ninety patients with rheumatoid arthritis with similar condition were selected from our hospital for a series of clinical trials.The patients were treated from May 2016 to November 2018.The 90 patients with rheumatoid arthritis were divided into two groups,45 patients in each group.One group of patients with rheumatoid arthritis was detected by rheumatoid factor test,the other group was detected by anticyclic citrullinated peptide antibody combined with rheumatoid factor test,and then the results of the two groups of patients with rheumatoid arthritis were compared.Results 42 patients in the experimental group were positive,the positive detection rate was 93.3%;32 patients in the control group were positive,the positive detection rate was 83.6%;the positive detection rate of the experimental group was significantly higher than that of the control group,the different was statistically significant(P<0.05),with statistical significance.Conclusion The positive detection rate of anti-cyclic citrullinated peptide antibody combined with rheumatoid factor in the diagnosis of rheumatoid arthritis is high,which has high diagnostic value and deserves further promotion.