艾司西酞普兰联合心理疗法在抑郁症合并下肢静脉血栓患者中的疗效观察及安全性研究

Efficacy and Safety of Excitalopram Combined with Psychotherapy in Patients with Depression Complicated with Lower Limb Venous Thrombosis

目的探讨艾司西酞普兰联合心理疗法在抑郁症合并下肢静脉血栓患者中的临床治疗效果及安全性。方法选择2017年3月—2019年3月治疗的抑郁症合并下肢静脉血栓患者86例作为对象,随机数字表分为对照组(n=43)和观察组(n=43)。对照组给予艾司西酞普兰治疗,观察组在对照组基础上联合心理疗法治疗,比较两组患者治疗前后的焦虑和抑郁情况及治疗后不良反应发生情况。结果治疗后两组患者HAMD评分和HAMA评分与治疗前相比,差异有统计学意义(P<0.05);观察组治疗后HAMD评分和HAMA评分均优于对照组,差异有统计学意义(P<0.05)。经治疗观察组不良反应发生率(18.60%)明显低于对照组(37.21%),差异有统计学意义(P<0.05)。结论将艾司西酞普兰联合心理疗法用于治疗抑郁合并下肢静脉血栓临床疗效显著,能够有效地改善患者的焦虑、抑郁心理,减少不良反应的发生,安全性高,值得推广应用。

Objective To investigate the clinical efficacy and safety of escitalopram combined with psychotherapy in patients with depression complicated with venous thrombosis of lower extremities.Methods 86 patients with depression complicated with venous thrombosis of lower limbs treated from March 2017 to March 2019 were randomly divided into two groups:control group(n=43)and observation group(n=43).The patients in the control group were treated with escitalopram,and the patients in the observation group were treated with psychotherapy on the basis of the control group.The anxiety and depression of the two groups before and after treatment and the occurrence of adverse reactions after treatment were compared between the two groups.Results After treatment,the scores of HAMD and HAMA in the two groups were significantly lower than those before treatment,the difference was statistically significant(P<0 05),and the scores of HAMD and HAMA in the observation group after treatment were better than those in the control group(P<0 05).The incidence of adverse reactions in the treatment group(18.60%)was significantly lower than that in the control group(37.21%),the difference was statistically significant(P<0.05).Conclusion To combine Escitalopram Combined psychotherapy is effective in the treatment of depression complicated with venous thrombosis of lower extremities.It can effectively improve the anxiety and depression of the patients,reduce the occurrence of adverse reactions,and has high safety,so it is worth popularizing and applying.