信号素3A与肾脏疾病

Role of semaphorin 3A in the occurrence or progression of kidney diseases

信号素3A(Sema 3A)属于轴突导向因子家族中一种分泌型蛋白,在足细胞分化、肾小球滤过屏障形成和血管内皮细胞迁移过程中起重要调节作用。研究发现,Sema 3A过表达可诱导肾足细胞足突消失或发育延迟,抑制输尿管芽分支和肾小球血管正常形成,导致肾小球发育不良和蛋白尿。而且,Sema 3A还是急性肾损伤、糖尿病肾病和狼疮性肾炎的生物标志物和潜在治疗靶点,本文对近年来Sema 3A在肾脏病发生中作用研究进展作一阐述。

Semaphorin 3A is a kind of secretory proteins in the family of axon-directed factors,which play an important role in the course of podocyte differentiation,glomerular filtration barrier formation and vascular endothelial cell migration. The studies found that the over expression of semaphorin 3A induced disappear or development delay in podocyte foot processes,the formation failure of ureteral branch and glomerular blood vessels,leading to glomerular dysplasia and proteinuria. Also,semaphorin 3A is considered as an important biomarker and the potential therapeutic target in the development of kidney disease,such as acute kidney injury,diabetic nephropathy and lupus nephritis. In this paper,we made an update statement of semaphorin 3A in the development of kidney disease in recent years.