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促性腺激素释放激素激动剂长、短方案对高龄患者体外受精-胚胎移植的影响研究 被引量:3

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摘要 目的探讨在IVF-ET治疗中,促性腺激素释放激素激动剂(GnRH-a)长、短方案应用于高龄患者的临床效果。方法回顾性分析2016年4月至2017年12月在我院生殖中心接受IVF/ICSI-ET助孕治疗的高龄(≥35岁)不孕症患者166个周期的临床资料,根据促排卵方案的不同分为长方案组(82例)和短方案组(84例),比较两组患者的实验室指标和妊娠结局。结果两组患者的一般资料比较无显著性差异(P>0.05)。长方案组的Gn用药时间、Gn用量略高于短方案组,但无显著性差异(P>0.05)。HCG注射日血清E2水平长方案组显著高于短方案组,LH水平则显著低于短方案组(P<0.05);两组患者的内膜厚度比较无显著性差异(P>0.05)。长方案组的获卵数[(11.9±1.2)vs.(7.1±1.4)个]、MⅡ卵母细胞数[(9.2±1.7)vs.(4.8±0.6)个]、正常受精卵数[(5.6±0.7)vs.(3.2±0.4)个]显著高于短方案组(P<0.05),但两组的优胚率、冷冻胚胎数比较无显著性差异(P>0.05)。长方案组和短方案组的临床妊娠率比较无显著性差异(20.7%vs.26.2%,P>0.05)。结论与GnRH-a短方案相比,虽然长方案的Gn用量略多,治疗时间略长,但对于高龄患者,长方案能募集到更多的卵母细胞,不失为一种好的促排方案。
出处 《生殖医学杂志》 CAS 2019年第4期416-419,共4页 Journal of Reproductive Medicine
基金 国家自然科学基金项目(81471478)
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