妊娠合并糖尿病及孕期血糖控制与胎儿畸形的关系

Analysis of the Relationship Between Blood Glucose Control in Pregnancy with Diabetes and Pregnancy and Fetal Malformation

目的:探讨与分析妊娠合并糖尿病及孕期血糖控制情况对胎儿畸形的影响。方法:从周口市人合医院2014年1月至2017年1月内接收的妊娠合并糖尿病患者中,随机抽取120名患者,孕期血糖控制情况良好的60名患者作为观察组,孕期血糖控制情况较差的60名患者作为对照组。两组患者均接受血糖控制措施进行干预,包括饮食、运动干预,并遵从医嘱对患者注射胰岛素进行治疗。对比两组患者空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)情况以及胎儿畸形情况。结果:观察组FBG、TC、TG水平均优于对照组且胎儿畸形发生率低于对照组,差异具有统计学意义(P <0.05)。结论:妊娠合并糖尿病患者容易导致胎儿的畸形,孕期血糖的控制影响到母婴预后,可改善妊娠结局,并降低了胎儿畸形的发生率。

Objective To investigate and analyze the effect of blood glucose control in pregnancy with diabetes and pregnancy on fetal malformation.Methods During January 2014 to January 2017 from Zhoukou hospital received the pregnancy associated with diabetes,randomly selected 120 patients,which were randomly sorted,60 patients with good glycemic control during pregnancy as the observation group,poor glycemic control during pregnancy in 60 patients as control group.The two groups were treated with blood glucose control measures,including diet,exercise intervention,and treatment of insulin injections in compliance with the doctor’s orders.The cases of fasting blood glucose,total cholesterol,three triacyl glycerol and fetal malformation were compared in the two groups.Results The levels of FBG,TC and TG in the observation group were all better than those in the control group and the incidence of fetal malformation was lower than that of the control group,and the results were statistically signi?cant(P<0.05).Conclusion Gestational diabetes mellitus is easy to cause fetal malformation.The control of blood glucose during pregnancy can affect the prognosis of maternal and infant,which can improve pregnancy outcome and reduce the incidence of fetal malformation.