谷氨酸转运体、谷氨酸/胱氨酸转运体与谷氨酸神经细胞毒作用

Relationship between glutamate transporter, glutamate/cysteine transporter and neurotoxicity induced by glutamate

谷氨酸转运体与谷氨酸 胱氨酸转运体在脑缺血疾病中起重要作用 ,谷氨酸转运体的结构或功能改变可使细胞间隙的谷氨酸浓度急剧升高 ,激活NMDA受体产生一系列的表现 ,同时抑制谷氨酸 胱氨酸转运体对胱氨酸的摄取 ,介导谷胱苷肽耗竭、氧自由基升高、胞内钙升高、线粒体损伤、细胞色素c释放等神经细胞毒环节 ,激活半胱天冬酶诱导凋亡。可进一步加重谷氨酸的神经细胞毒作用。

This paper introduces the relationship between glutamate transporter, glutamate/cysteine transporter and neurotoxicity induced by glutamate. Under pathologic conditions, glutamate transporters release glutamate to activate glutamate receptors, and inhibit the uptake of glutamate/cysteine transporters, which induces downstream changes. Among these changes oxygen derived free radidicals affects the function of glutamate transporter and enhances the neurotoxicity of glutamate. All these can lead to neurocyte death. Glutamate transporters release glutamate to inhibit the uptake of glutamate/cysteine transpoter and activate glutamate receptor. The inhibition of glutamate/cysteine transpoter affects the function of glutamate transporter. Two transporters interaction and the downstream changes lead to neurocytes death.