自体骨髓移植治疗复发/难治急性白血病疗效观察

The observation of efficency on treatment for 3 cases with relapse/refractory a cute leukemia with autologous bone marrow transplantation

目的 :探讨自体骨髓移植对复发 难治急性白血病的治疗效果。方法 :选取 3例患者作为研究对象 ,3例患者中 ,急性淋巴细胞白血病 1例 ,急性髓细胞白血病 2例 ,初治时均以标准诱导化疗方案化疗 1疗程未达到完全缓解 (CR) ,第 2疗程重复诱导化疗方案后达到完全缓解 ,巩固化疗过程中 ,患者于第 6— 8疗程复发 (中位数第 7疗程 ) ,CR2 至ABMT的中位时间为 5月 ,预处理方案为CBV(即BCNU +CTX +VP 16 ) ,采集骨髓悬液约 2 5 0～ 880ml,中位数 5 90ml,含单个核细胞数为 1 5 4～ 2 3× 10 8 kg ,中位数 1 94× 10 8 kg ,采集后 4℃冰箱保存6 0小时。结果 :患者通过。细胞期 ,白细胞升至 0 5× 10 9 L的中位数时间为 2 7天 ,血小板计数上升至 2 0×10 9 L的中位数时间为 36天 ,骨髓恢复正常工作造血的中位数时间为 33天。结论 :自体骨髓移值是一种有价值的治疗方法。

Objective To exeplore autologous bone marrow transplantation (ABMT) treatment effect on relapse/refractory acute leukemia. 3 cases were treated by regular chemotherapy, one of patients was acute lymphatic leukemia, 2 were acute myelid leukemia, 3 cases were second complete remission, and by BCNU?Cylophosphamide and Etoposide (CBV) were conditioning regimen, patients who received 1.54～2.3×10 8 (median 1.94×10 8) nucleated cells /kg. Results 3 cases passed 0 cell phase, median time to recovery was 27 days for neutrophils(PMN) and 36 days for platelets, after median time 33 days, function of bine marrow rebuilded, 2 cases were alive, 1 case was relapsed, without trandsplant relative morbidity. Conclusion ABMT is especially of high value.