摘要
采用线形扫描伏安法和循环伏安法研究了抗癌新药氟哌酸基甲硫酰 (1 苯基甲撑 ) 肼 (F2 )的电化学行为。实验结果表明 ,F2 在电极表面存在吸附特性 ,在 0 0 5mol/L的NH3 NH4Cl缓冲溶液中 ,该药物在- 0 73V(vs.SCE)处有一灵敏的还原峰 ,在选定的最佳条件下 ,其浓度在 (0 2～ 4 0 )mol/m3 之间时与其峰电流有良好的线形关系 ,检测限为 0 0 5mol/m3 。方法用于检测模拟尿、血清样品中痕量药物的测定 ,回收率均在 97 9%～ 10 1 8%。
The voltammetric behavior of new anticancer drug norfloxacinylcarbothioic (1 phenyl methylene) hydrazone(F 2) has been studied by means of linear potential sweep voltammetry and cyclic voltammetry.The results showed in the medium of 0.05 mol/L NH 3 NH 4Cl,a sensitive peak is observed at -0.73V(vs.SCE).The peak current is proportional to the concentration of F 2 in the range of (0.2～40) mol/m 3 and the detection limit is 0.05 mol/m 3. The method is applied to the determination of trace F 2 in mimic samples of human urine and blood serum without pretreatment.The recovery was 97.9%～101.8%.
出处
《应用化工》
CAS
CSCD
2002年第6期32-34,共3页
Applied Chemical Industry
基金
浙江省自然科学基金 (No .2 990 0 9)
浙江省分析测试基金资助项目 (No .0 10 35 )
