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肽核酸与核酸分子杂交的模式及其在基因诊断领域中的应用 被引量：4

Model of PNA Hybridization with Nucleic Acid Molecular and its Applications in Genetic Diagnosis
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摘要 在发明肽核酸(peptide nucleic acid,PNA)后的短短十年间,由于PNA分子独特的生物学性能,使之可以与DNA及RNA分子通过不同的机制形成稳定的复合物,导致PNA在基因诊断领域有得天独厚的优势。本文综述了PNA与核酸分子杂交的几种不同模式以及最近几年PNA在基因诊断领域的一些最新进展。
作者 陈鸣 府伟灵
机构地区 第三军医大学附属西南医院检验科
出处 《生命的化学》 CAS CSCD 2003年第5期353-355,共3页 Chemistry of Life
基金 国家863计划重大专项(2002AARZ2023) 国家自然科学基金(3027038) 重庆市应用基础研究项目(2002-10-78)资助项目
关键词 肽核酸 杂交 基因诊断
分类号 R346 [医药卫生—基础医学]
  • 相关文献

参考文献20

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二级参考文献13

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共引文献12

同被引文献36

  • 1王传玺,韩金祥,鲁艳芹.肽核酸在分子生物学方面的应用研究进展[J].中国生化药物杂志,2004,25(5):320-320. 被引量：2
  • 2谢勇恩.第三代反义核酸技术—肽核酸[J].川北医学院学报,2007,22(4):309-313. 被引量：3
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  • 10De Koning MC, Van der Marel GA, Overhand M, et al. Synthetic developments towards PNA-peptide conjugates[J]. Curr Opin Chem Biol, 2003,7(76) :734-740.

引证文献4

二级引证文献8

生命的化学
2003年 第5期

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