期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CD44v6在胰腺癌组织中的表达及意义

Expression of CD44 Variant Exon 6 in Pancreatic Cancer
下载PDF
导出
摘要 目的 :探讨CD4 4v6表达与胰腺癌淋巴结转移、增殖活性的关系。方法 :应用免疫组化SP法检测 6 2例胰腺癌组织中CD4 4v6的表达。结果 :CD4 4v6的阳性率为 5 4 .84 % ;伴淋巴结转移者CD4 4v6的阳性率 (6 8.75 % ) ,明显高于无淋巴结转移者 (40 .0 0 % ) ,两组相比差异显著 (P <0 .0 5 ) ;CD4 4v6表达与胰腺癌增殖之间无一致性。结论 :CD4 Objective: Our aims were to evaluate the expression of CD44v6 in tissues of pancreatic cancer and to investigate its relationship with transformation and invasiveness of pancreatic cancer. Methods:The expression of CD44v6 was determined with SP immunohistochemical technique. Results:The positive rate of CD44v6 was 54.84%,while the positive rate in patients with lymph node metastasis was 68.75%, which was significantly higher than those without lymph node involvement(P<0.05). The proliferation of pancreatic cancer was not related to CD44v6. Conclusion:The expression of CD44v6 is closely related to metastasis and infiltration of pancreatic cancer.
作者 王鹏 李航宇 刘忠 刘万涛 张静
机构地区 中国医科大学附属第一医院肿瘤内科 中国医科大学附属第一医院普外科 沈阳市第七人民医院外科 本钢职工总医院急诊科 沈阳市生殖医学技术中心
出处 《中国医科大学学报》 CAS CSCD 北大核心 2003年第5期437-438,共2页 Journal of China Medical University
关键词 CD44V6 胰腺癌 转移 CD44v6 pancreatic cancer metastasis
分类号 R735.9 [医药卫生—肿瘤]
  • 相关文献

参考文献7

  • 1李玉军,张华,郝青.CD_(44)v6表达与胰腺癌增殖、转移及预后关系的研究[J].中国肿瘤临床,2000,27(4):268-270. 被引量：12
  • 2Stamenkovic I, Aruffo A, Amoit M. The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells[J]. Embo J, 1991 ,10(2) :343 -348.
  • 3Screaton GR, Bell MV, Jackson DG. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons[J]. Proc Natl Acad Sci USA,1992,89(24) :12160 -164.
  • 4Gunthert U, Hofmann M, Rudy W. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells[J]. Cell,1991,65( 1 ) :13 -24.
  • 5Koopman G, Heider KH, Horst E, et al. Activated human lymphocytes and aggressive non-Hodgkin' s lymphomas express a homologue of the rat metastasis-associated variant of CD44[J]. J Exp Med,1993, 177(4):897-904.
  • 6Herrlich P, Zoller M, Pals ST, et al. CD44 splice variants: metastases meet lymphocytes[J]. Immunol Today, 1993,14(8) :395 -399.
  • 7Piselli P, Vendetti S, Vismara D. Diffenrent expression of CD44,ICAM-1, and HSP60 on primary tumor and metastases of a human pancreatic carcinoma growing in scid mice [ J ]. Anticancer Res,2000,20(2A) :825 - 831.

二级参考文献6

  • 1Jackson PA,Green MA,Pouli A,et al.Relation between stage,grade, proliferetion and expression of p53 and CD44 in adnomas and carcinomas of the colorectum[].Journal of Clinical Pathology.1995
  • 2Rall CJ,Rustgi AK.CD44 isoform expression in primary and metastatic pancreatic adenocarcinoma[].Cancer Research.1995
  • 3Kaufmann M,Heider KH,Sinn HP,et al.CD44 variant expression in primary breast cancer and length of survival[].The Lancet.1995
  • 4Mulder JW,Kruyt PM,Sewnath M,et al.Difference in expression of CD44 splice variant between proximal and distal adencarcinoma of large bowel[].British Journal of Surgery.1995
  • 5Gunthert U,Hofmann M,Rudy W,et al.A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells[].Cell.1991
  • 6Mirecka J,Mark D,Schauer A.Immunohistochemical localization of CD44 v ariant 5 and 6 in human gastric mucosa and gastric cancer[].Anticancer Research.1995

共引文献11

中国医科大学学报
2003年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部