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自身免疫调节因子(AIRE)的研究进展 被引量：1

Recent advance on researches of autoimmune regulator
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摘要 自身免疫调节因子(autoimmune regulator,AIRE)是一种具有转录活化潜能的DNA结合蛋白。由于AIRE基因的突变可导致自身免疫病APECED(autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy,APECED),又称自身免疫性多腺体综合征I(autoimmune polyg-landular syndrome type I, APS I)。因此,这一基因在正常生理状态下很可能对维持自身免疫耐受、控制自身免疫起着重要作用。对自身免疫耐受产生机制的揭示将为自身免疫病、超敏反应、移植排斥及肿瘤的治疗提供新的策略。本文对AIRE的基因鉴定、分子结构和生化功能、亚细胞定位、组织分布及其在自身耐受产生中的作用作一综述性介绍。 The autoimmune regulator(AIRE) showned DNA binding activity and transcrip-tional transactivation potential. Mutations in the AIRE gene were responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), and also called autoimmune polyglandular syndrome type I(APS I), so the gene could play important roles in maintaining the self-tolerance and preventing the autoimmune disease. Understanding the mechanisms of self-tolerance will help to find new strategies for treatment of autoimmune disease, hypersensitivity, transplantation rejection and tumor. In this review, we introduced the structure, functions, and tissue expression of AIRE gene/protein and its roles in self-tolerance.
作者 于春雷 刘丹 李一 杨贵贞
机构地区 吉林大学基础医学院免疫学教研室
出处 《生命科学》 CSCD 2003年第5期289-292,306,共5页 Chinese Bulletin of Life Sciences
关键词 自身免疫调节因子 转录因子 免疫耐受 自身免疫病 autoimmune regulator(AIRE) transcription factor self-tolerance autoimmune disease
分类号 R593.2 [医药卫生—内科学] Q501 [生物学—生物化学]
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参考文献31

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同被引文献8

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生命科学
2003年 第5期

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