奥沙利铂联合5-氟尿嘧啶与亚叶酸钙治疗大肠癌的临床分析

Oxaliplatin plus fluoriouracil and folinic acid combination chemotherapy in the treatment of colorectal carcinoma

目的 评价奥沙利铂 (艾恒 )联合亚叶酸钙、5 -氟尿嘧啶方案治疗大肠癌的疗效与毒副反应。方法奥沙利铂 (L -OHP) 130mg/m2 ,静滴 4小时 ,第一天 ;亚叶酸钙 (CF) 2 0 0mg/m2 ,静滴 2小时后 ,5 -氟尿嘧啶(5 -FU) 30 0mg/m2 ,静脉定量记时给药泵持续输注 10 - 15小时 ,第 1- 5天 ,每 3周重复 ,行 3周期治疗后判断疗效。结果 入组观察 2 6例大肠癌患者 ,其中Dukes’A3期 1例 ,Dukes’B期 7例 ,Dukes’C +D期共 18例 ,初治 18例 ,复治 8例 ,总有效率为 6 1.5 % ,进展期或晚期大肠癌有效率为 4 4 .4 %。不良反应大多为Ⅰ -Ⅱ度。结论 L -OHP(艾恒 ) +CF +5 -FU方案治疗大肠癌疗效高 ,不良反应轻 。

Objectives To evaluate the efficacy and toxicity of home made oxaliplatin plus fluoriouracil, and folinic acid combination therapy in the treatment of colorectal carcinoma.Methods twenty-six cases received oxaliplatin 130mg/m 2,d1;folinic acid 200mg/m 2,d 1-d 5 and fluoriouracil 300mg/m 2,d 1-d 5.The regiment was repeated every 21 days.Results There were Dukes' A 1 case, Dukes'B 7 cases, and Dukes'C+D 18 cases; the overall response rate was 61.5%. The advanced' response rate was 44.4%. The major toxic reactions were nausea, vomiting and peripheral neurotioxixity.Conclusions Oxaliplatin plus fluoriouracil and folinic acid combination therapy is positively effective and cheap in colorectal carcinoma. The toxicity is mild to moderate and reversible.