^(153)Sm-EDTMP治疗乳腺癌骨转移的临床疗效评价

Evaluation of Efficacy of ^(153) Sm-EDTMP in Patients with Painful Bone Metastases of Breast Cancer

目的 探讨 1 53Sm -乙二胺四甲基膦酸 (1 53Sm - EDTMP)治疗乳腺癌伴骨转移的临床效果。方法 对 76例乳腺癌骨转移疼痛患者采用两次给药法静脉注射 1 53Sm - EDTMP进行治疗并进行疗效评价。结果 治疗后骨痛完全缓解者 2 5例 ,中度缓解者 4 0例 ,总有效率为 85 .5 2 % (6 5 / 76 )。治疗后有 6例骨转移灶完全消失 ,16例转移灶数量减少或病灶缩小 ,总有效率为 2 8.95 % (2 2 / 76 )。未见严重的毒副作用 ,仅见 度以内的血液学毒性反应。结论 1 53Sm- EDTMP能快速、有效地缓解乳腺癌骨转移疼痛 ,且副作用小 ,是一种安全。

Objective To explore the therapeutic efficacy of 153 Sm EDTMP in treating painful bone metastases from breast cancer. Methods Seventy six patients with painful bone metastases from breast cancer entered the study and were treated by intravenous administration of 153 Sm EDTMP in two doses. Results Overall, 65 of 76 patients (85.52%) experienced prompt pain relief; among them 25 patients (32.89%) felt complete remission and 40 patients (52.63%) met with moderate remission. Follow up imaging examinations were performed after each course of treatment. Complete metastatic foci disappearance was achieved in 6 cases and partial metastatic foci disappearance or regression was achieved in 16 cases, so the global effective rate was 28 95%. No major adverse effects were observed, and hematological toxicity did not exceed grade 3 in accordance to the World Health Organization criteria. Conclusion 153 Sm EDTMP is safe and effective for fast palliation of painful bone metastases and for inhibition of metastatic foci from breast cancer.