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鞍上神经节细胞胶质瘤

Ganglioglioma of the Suprasellar Region
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摘要 报道十分罕见的鞍上神经节细胞胶质瘤 1例。患者 ,女性 ,15岁 ,因双上肢抽搐 1年 ,多尿、视力下降 2个月入院。查体 :双视乳头水肿 ,其余无神经系统阳性发现。MRI显示为鞍上的囊性占位病变 ,大小 4 cm× 3cm×3cm,轻度梗阻性脑积水。血中 GH、PRL、THAC、TSH、L H、FSH、TT3、TT4、CORT- 1都在正常水平。手术经右侧室穹隆柱间入路全切除病灶。组织经石蜡切片及免疫组化染色 ,胶质纤维酸性蛋白 (GFAP) +,神经丝蛋白 (NF)+,病理诊断为神经节细胞胶质瘤。随访 10个月 ,患者学习生活良好。神经节细胞胶质瘤有特殊的组织学发生、临床表现和病理学特点。该肿瘤如能获得早期诊断及手术全切 。 Ganglioglioma is a lesion rarely encountered in the suprasellar region. Here we present a case of suprasellar region ganglioglioma that was totally removed by surgery. The patient was a 15 year old female who complained of seizure for about 1 year, polyuria and eyesight descent for about 6 months. The neurological examination was without positive findings except bi papilledema. By MRI, a huge cystic mass lesion was found in the suprasellar region, which caused slight obstructive hydrocephalus. The size of the mass was determined to be 4 cm×3 cm×3 cm. The levels of GH, PRL, ACTH, TSH, LH, FSH, TT3, TT4, CORT 1 were normal. We resected this lesion totally by trans anterior portion of the foramen of right lateral ventricle. The postoperative paraffin section and immunohistochemistry showed ganglioglioma, GFAP(+), CK(-), NF(+).The follow up time was 10 months; the patient was in good condition and enjoyed high quality of survival. This tumor has special embryological origins, clinical manifestations, and pathological features. Ganglioglioma of the suprasellar region will be of relatively favorable prognosis if it is diagnosed and resected in the early stage.
出处 《四川大学学报(医学版)》 CAS CSCD 北大核心 2003年第4期756-758,共3页 Journal of Sichuan University(Medical Sciences)
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参考文献11

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