慢性肾衰竭患者C-反应蛋白与营养不良及感染的关系

Correlation with C-reactive protein,malnutrition and infection in patients with chronic renal failure

目的 探讨慢性肾衰竭患者C 反应蛋白 (CRP)与营养不良及感染的关系。方法 将5 1例受检的慢性肾衰竭患者分为感染组和非感染组 ,检测其CRP、白蛋白 (Alb)、前白蛋白 (PA )和血肌酐 (Scr)及胆固醇 (TCH)水平。结果 感染组CRP水平明显高于非感染组 (P <0 .0 1) ,感染组血浆白蛋白、前白蛋白及血浆白蛋白 /血肌酐 (Alb/Scr)比值明显低于非感染组 (P <0 .0 1) ,两组间血肌酐和胆固醇比较差异无显著性 (P >0 .0 5 )。慢性肾衰竭患者CRP水平与血浆白蛋白、前白蛋白水平及血浆白蛋白 /血肌酐比值呈负相关 (P <0 .0 1) ,CRP水平与血肌酐及胆固醇的相关性不显著 (P >0 .0 5 )。

Objective To explore the relationship between C-reactive protein(CRP)and malnutrition,infection in patients with chronic renal failure.Methods Fifty-one patients with chronic renal failure were divided into infection group and non-infection group.The blood CRP,albumin,pre-albumin,creatinine and cholesterol were detected.Results Blood CRP level in infection group was higher than that in non-infection group(P<0.01).Blood albumin,pre-albumin and albumin- creatinine ratio in infection group were lower than those in non-infection group(P<0.01).No difference of blood creatinine and cholesterol between two groups was found(P>0.05).Blood CRP level was correlated with blood albumin,pre-albumin and albumin- creatinine ratio negatively(P<0.01).Blood CRP was not correlated with blood creatinine and cholesterol(P>0.05).Conclusion Blood CRP can reflect nutriture and inflammatory reaction of patients with chronic renal failure.