检测慢性支气管炎患者血清、痰中白细胞介素及C-反应蛋白的临床意义被引量：5

导出

摘要目的　评价血清和痰中白细胞介素 (IL)以及C 反应蛋白 (CRP)的改变在慢性支气管炎 (慢支炎 )急性期的临床意义。方法　对慢支炎急性期及缓解期患者进行血清、痰、诱导痰中IL 4、IL 6、IL 8及血中CRP作定量检测 ,并与健康健康体检者 (对照组 )比较。结果　 (1)慢支炎急性期组患者血清、痰、诱导痰中IL 4、IL 6、IL 8、CRP较慢支炎缓解期组和对照组增高 (P <0 .0 5 )。(2 )慢支炎缓解期组与对照组的痰、诱导痰IL 4、IL 6、IL 8及血清CRP的含量比较差异有显著性(P <0 .0 5 ) ,而慢支炎缓解期组与对照组的血清IL 4、IL 6、IL 8比较差异无显著性 (P >0 .0 5 )。结论　慢支炎急性期患者 3种标本中IL 4、IL 6、IL 8及CRP浓度升高。

作者杨恂官和立姚薇徐丽蓉徐晓梅胡蓉李卉

机构地区成都铁路局中心医院

出处《临床内科杂志》 CAS 北大核心 2003年第10期539-540,共2页 Journal of Clinical Internal Medicine

关键词白细胞介素 C-反应蛋白支气管炎

分类号 R562.21 [医药卫生—呼吸系统]

引文网络
相关文献

参考文献9

1Hamzaoui A,Brahimm B,Zhioua A,et al. Inflammatory response in induced sputum menonuclear cells from patient with acute exacerbation of asthma. Mediators inflamm ,2000,9 : 143-153.
2Zhn J, Majumdar S, Qui Y, et al. Interleukin-4 and interleukin-5 gene expression and inflammation in the mucus-secreting glands and subepithelid tissue of smokers with chronic bronchitis lack or relation ship with CDS( + )cells. Am J Respir Grit Care Med,2001,164:2220-2228.
3Vanagihara K,Tomono K, Kurok M, et al. Intrapulmonary concentrations of inflammatory cytokines in a mouse model of chronic respiratory infection caused by Pseudomonas aeruginosa. Clin Exp Immunol,2001,122:67-71.
4Aaron SD,Angel SB,Lunau M,et al. Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease. Am J Respin Crit Care Med,2001,163:349-355.
5Hull J, Thomson A, Kwiakowski P. Association of respiratory syncytial virus bronchiolitis with the interlenkin-8 gene region in UK families. Thorax,2000,55 : 1023-1027.
6Scholma J, Slabos DJ, Boezen HM, et al. Eosinophilic granulocytes and interleukin-6 level in bronchoalveolar lavage fluid are associated with the development of obliterative bronchiolitis after lung transplantation. Am J Respin Grit Care Med,2000,162 :2221-2225.
7Sanden M,Irwin M,Sinha P,et al. Suppression of interleukin-6 to interleukin-10 rate in chronic alcoholics: association with postoperative infections. Intensive Care Med,2002,28:285-292.
8Dollner H, Vatten L, Linneoo J, et al. Inflammaory mediators in umbilical plasma form neonates who develop early-onset sepsis. Biol Neonate,2001.80:41-47.
9Crooks SW, Bayley DL, Hill SL, et al. Bronchial inflammation in acute bacterial exacerbation ofchronie bronchitis:the rate of leukotriene B4.Eur Pespir J,2000,15:274-280.