摘要
采用化学共沉淀法先生成Fe3O4微粒,再将其分散于含有表面活性剂的水中的方法制备了纳米级Fe3O4磁性粒子.通过双层表面活性剂包覆可使Fe3O4磁性粒子稳定分散于水中而不聚集.在反应溶液pH值为11～12,温度为60℃及油酸钠为第1层表面活性剂,十二烷基苯磺酸钠为第2层表面活性剂的条件下制备了粒径为36nm的Fe3O4磁性粒子.实验结果表明:反应溶液pH值和表面活性剂是影响Fe3O4磁性粒子稳定性、粒径和饱和磁化强度的主要因素;利用XRD和IR证实了Fe3O4磁性粒子中存在Fe3O4和表面活性剂结构.所制备的纳米级Fe3O4磁性粒子可用作导向药物的磁载体.
Fe3O4 magnetic nanoparticles are synthesized by a sequential process involving the chemical coprecipitation of Fe2+ and Fe3+ salts with sodium hydroxide(NaOH) followed by resuspension of the ultrafine particles in water using surfactant. This procedure produces nanoparticles stabilized against agglomeration by bilayers of surfactant encapsulating the nanoparticles. Experiment results indicate that pH value of the reactive solution, surfactant have great effects on the stability, size and saturation magnetic intensity of the Fe3O4 magnetic particles. Under the conditions of pH 11～12, 60 ℃ and sodium oleate as the primary surfactant, sodium dodecyl benzene sulfonate as the secondary surfactant, Fe3O4 magnetic particles with a size of 36 nm and higher saturation magnetic intensity are obtained. XRD and IR analysis measurement results show the existence of Fe3O4 and surfactant structure. The Fe3O4 magnetic particles can be used as targeteddrug carriers.
出处
《中南工业大学学报》
CSCD
北大核心
2003年第5期516-520,共5页
Journal of Central South University of Technology(Natural Science)
基金
国家"863"高技术计划项目(2001AA218011)
