珠黄霜对肛门术后创面愈合的临床实验观察

Clinical and Experimental Study on the Treatment Anal Surgical Wound with Zhuhuang Frost

目的 :观察外用中药珠黄霜对肛门术后创面肉芽组织中羟脯氨酸 (HYP)变化。方法 :将 5 0例低位单纯性肛瘘术后患者随机分为珠黄霜治疗组和马应龙麝香痔疮膏阳性药物对照组 ,分别在术后第 3、7、14天创面肉芽组织上取材 ,应用碱水解比色法检测 HYP的含量。结果 :术后第 7、14天创面 HYP含量治疗组显著高于对照组 ,第 3天二者差异无显著性。结论 :珠黄霜能显著提高肛门术后创面肉芽组织中

Objective: To observe the effect of Zhuhuang Frost (ZHF), an external preparation of Chinese herbal medicine on level of hydroxy-proline (HYP) in surgical wound after an operation. Methods: Fifty postoperation patients after low position simple operation of anal fistula were randomly divided into two groups and treatd with ZHF and Mayinglong Musk hemorrhoidal paste (MMHP) respectively. The level of HYP in granulation of wound was tested using alkaline hydrolysis assay at the 3rd, 7th and 14th day after operation respectively. Results: The HYP level tested at the 7th and 14th day after operation in the ZHF treated group was higher than that in the MMHP treated group,but those tested at the 3rd postoperational day in the two groups were not different significantly. Conclusion: ZHF could increase the HYP level in postoperational granulation of wound after anal operation.