钼中毒对骨骼力学性质影响的实验研究

Experimental study on the Mo poisoning's effect on the biomechanical nature of bone

目的 研究了钼中毒对绵羊骨骼生物力学性质的影响。方法 绵羊 16只 ,随机分成 4个组 ,对照组不投Mo ,A组每天投Mo 60mg/kg·w ;B组投Mo每天 3 0mg/kg·w ;C组每天投Mo 15mg/kg·w ;连续投Mo 15 0d后将绵羊捕杀 ,取新鲜骨骼用极普法测定Mo含量 ,用KMnO4滴定法测试骨骼的Cu、Mg等微量无素的含量。还测定了血清碱性磷酸酶含量 ,测试了肱骨的扭转剪应力、骨的冲击韧性等机械性能指标。结果 得出了各组骨骼Mo、Cu、Mg含量 ,还得出了各组骨骼扭转剪应力、冲击韧性等力学性能指标。结论 高Mo不引起骨骼Cu缺乏 ,Mo对绵羊血清碱性磷酸酶无太大影响 。

Objective To research about the mo poisoning effect on the mechanical natures of sheep's bones. Methods After dividing sixteen sheep into four groups at random, one of the groups was taken as contrasting and the others as treating groups. The former was not fed with Mo. But among the treating groups: group A was given 60 mg of Mo per kg of sheep weight each day, group B 30 mg, group C 15 mg. Through 150 days of continuous feeding Mo. These sheep were killed to provide fresh femoral bones to be determined Mo content with polarogram. By KMnO 4 titration, measured the content of the trace elements, such as Cu and Mg etc. In addition. Measured the content of the PCP . Did the torsion test and impact test on them. Results Got the content of the trace elements, such as Mo,Cu and Mg etc and the torsion stress of the humerus and impact tenacity . Conclusions More Mo can't lead to less Cu. There are little effects of Mo on the serum PCP. The indexes of mechanical natures of the most Mo group are strikingly lower than those of the control group.