异长春花碱单药化疗75岁以上高龄晚期非小细胞肺癌

Single-agent Vinorelbine in the Treatment of Elderly Patients with Advanced Non-small-cell Lung Cancer

目的 评价异长春花碱单药化疗对高龄晚期非小细胞肺癌患者生活质量的影响及其耐受性。方法 治疗 75岁以上高龄晚期非小细胞肺癌 38例。治疗组 2 0例予以异长春花碱 (NVB) 2 5mg/m2 第 1,8天 ,2 8天为一疗程 ;对照组 18例辅以最佳的支持治疗(BSC)。结果 治疗组有效率 2 0 %,对照组有效率 0。结论 对高龄晚期非小细胞肺癌患者 ,异长春花碱单药化疗较支持治疗有更好的疗效和生活质量 ,更长的生存期 ,且毒副作用轻微 ,可以耐受。

Objective In this report we have evaluated whether the sing-agent therapy with vinorelbine(V group) may obtain a high response rate, with acceptable toxicity and improvement in survival and quality of life, comparing with the therapy with supportive care(S group) among elderly patients aged over 75.Methods There were 38 patients with advanced NSCLC.20 of whom were allocated to receive NVB 25 mg/m 2 intravenous infusion on days 1,8;18 of whom were allocated to receive supportive care.The patients received a minimum of two courses unless progressive disease was detected.Results V group: CR 0,PR 4,CR+PR 20%,median survial time was 6 months.S group:CR 0,PR 0,CR+PR 0 median survival time was 2 months.Conclusion In elderly patients with NSCLC,single-agent vinorelbine treatment is associated with better effect, better survival and better quality of life than supportive care.Its toxicity is mild and acceptable.