Alzheimer病红细胞电泳行为的改变

The reduce of the time of erythrocyte electrophoresis in Alzheimer disease

目的 观察 Alzheimer病 (AD)患者红细胞电泳指标的改变。方法 用实验条件下的红细胞电泳系统分别测定 AD、血管性痴呆(VD)及老年组红细胞电泳时间的数值。结果 AD患者红细胞电泳时间明显缩短。如以红细胞电泳时间小于 1 2 .74s(老年组数据 90 %的单侧下限值 )为阳性界限 ,则 AD、VD及老年组的红细胞电泳指标阳性率分别为 81 .82 % (P<0 .0 0 1 )、76.92 % (P<0 .0 0 1 )和 7.55%。结论 红细胞电泳时间的缩短与 AD高度相关。

Objective To observe the characteristics of erythrocyte electrophoresis in the diagnosis of Alzheimer disease.Methods With the experimental erythrocyte electrophoresis system, the values of the time of erythrocyte electrophoresis of Alzheimer disease, multiple infarct dementia and old controls were tested.Results The time of erythrocyte electrophoresis of Alzheimer patient was significantly reduced. If positive standard of erythrocyte electrophoresis was less than 12.74 sec(the lower limit of 90% of normal old control), the positive rates of Alzheimer disease, multiple infarct dementia and old control were 81.82% ( P <0.001), 76.92% ( P <0.001) and 7.55% respectively.Conclusions The reduce of the time of erythrocyte electrophoresis is a marker of Alzheimer disease.