绝经后妇女糖耐量及胰岛素抵抗研究

Study on the glucose tolerance and the resistance to insulin for menopause women

目的 :探讨绝经后妇女糖耐量变化及其相关因素。方法 :通过对绝经后妇女 (B组 ) 2 7例及对照组 (A组 ) 1 4例进行口服葡萄糖耐量试验 (OGTT)及胰岛素释放试验 ,测定其空腹、餐后两小时的血糖及胰岛素值 ,计算胰岛素敏感性指标 (IAI)及胰岛素抵抗指数 (HOMA IR)并进行比较。结果 :B组与A组相比空腹及餐后两小时血糖值明显增高 (P <0 0 0 1 ) ,IAI显著低下(P <0 0 0 1 ) ,HOMA IR明显增高 (P <0 0 0 1 )。结论

Objective:To explore the changes and its relatively influence factors of the glucose tolerance for menopause women.Methods:By checking up the blood sugar and the insulin for the menopauce patients,who took the oral glucose tolerance test(OGTT) and insulin release test in fast state and two hours after the meal,who were divided into two groups,one group including 27 cases(B group) and the other 14 cases(A group,control group),the index of anti insulin(IAI) and the index of anti insulin resistance(HOMAIR) were counted and compared with each other.Results:The value of the blood sugar and HOMAIR for the patients in group B in the fast state and the two hours after the meal were significantly increased then that in the group A(P<0 01 and P<0 001 respectively).while the IAI decreased markedly(P<0 001).Conclusions:The decrease of glucose tolerance and resistance to insulin exist among the menopause women.