各种肝病的肝纤维化标志改变的探讨

Changes of liver fibrosis markers in different kinds of hepatitis

目的 :探讨各种肝病患者血清肝纤维化标志的改变 ,甘草酸二胺注射液对肝脏炎症、纤维化指标的作用。方法 :用放免法检测透明质酸 (HA)、层粘蛋白 (LN)、Ⅲ型前胶原多肽 (PCⅢ )。结果 :急性肝炎的三种肝纤指标均升高 (P <0 0 5 )。急黄肝高于急无黄肝 (P <0 0 5 )。慢性肝炎 1 1 2例 ,三项肝纤指标显著高于正常对照 (P <0 0 5 )。慢肝重度显著高于慢肝轻度 (P<0 0 0 1 )。肝硬化的三项肝纤指标又显著高于慢肝 (P <0 0 0 1 ) ,其它肝病的肝纤指标也升高。 2 5例慢肝用甘草酸二胺注射液治疗 2月 ,ALT、AST、GGT显著降低 (P <0 0 1 )。三项肝纤指标中HA降低较显著 (P =0 0 5 ) ,LN和PCⅢ虽有降低 ,但差异不明显 (P =0 4 5 9,P =0 1 92 )。结论 :各种肝病的三项肝纤维化指标均升高 ,以慢肝重度 ,肝硬化升高明显。

Objective:To research the changes of serum liver firosis markers in patients with different kinds of hepatitic diseases.Methods:HA,LN,PCⅢ were measured by radioimmunoassay.Results:Three markers of liver fibrosis all higher in acute hepatitis(P<0 05),and it was also higher in the rest patients.It was obviously higher in acute nonicteric hepatitis,controlled group and mild chronic patients respectively.ALT,AST and GGT were markablely decreased in 25 patients after 2 months treatment of diammonium glycyrrhizinate injection(P<0 01).HA showed significant differences in three liver fibrosis markers(P=0 05),reversely,in LN and PCⅢ(P=0 459,p=0 192).Conclusion:Three markers of all kinds of liver diseases are high,especially in patients with serious chronic hepatitis and cirrhosis.Diammonium glycyrrhizinate injection has anti inflammatory and improvement effects on liver fibrosis.