血清IL-6、TNFα、sICAM-1与肝细胞损伤的相关性观察

Serum Concentration of Soluble Intercellular Adhesion Molecule-1, Tumor Necrosis Factor and Interleukin-6 and Its Clinical Significance in Chronic Viral Hepatitis

目的 了解HBV感染者血清可溶性细胞黏附分子-1(soluble Intercellular adhesion molecule-1,sICAM-1)、肿瘤坏死因子α(tumor necrosis factor α,TNFα)和白细胞介素-6(interleuhin-6,IL-6)水平与肝细胞损伤的关系。方法 以ELISA法检测慢性乙型肝炎病人、肝硬化、慢性无症状HBV携带者(chronic asymptomatic HBsAg carriers,AsC)和正常人血清sICAM-1、TNFα、IL-6的水平;并比较血清ALT变化。结果 慢性乙型肝炎病人和肝硬化病人血清sICAM-1、TNFα、IL-6水平升高,并与ALT升高成正比,而正常人和慢性无症状HBV携带者表现正常。结论 sICAM-1、TNFα、IL-6与HBV感染的肝细胞损伤相关。

Objective To study the relation between serum levels of soluble intercellular adhesion molecule-1 (sICAM-1), tumor necrosis factor α(TNFα) and interleukin-6 (IL-6) and liver damage in patients with viral hepatitis B. Methods Serum levels of sICAM-1 ,TNFα and IL-6 in chronic viral hepatitis,chronic asymptomatic HBsAg carriers and healthy persons was measured by ELISA. Results Serum levels of sICAM-1 ,TNFa and IL-6 in chronic viral hepatitis were significantly increased,compared with healthy persons and AsC. There were significantly positive correlation among serum levels of sICAM-1 ,TNFa and IL-6 and serum ALT. Conclusion Serum concentration of soluble intercellular adhesion molecule-1,tumor necrosis factor a and interleukin-6 were significantly increased in the HBV infected patients with the damage liver.