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严重急性呼吸综合征康复者志愿特殊献浆前健康检查分析

Examinations of the recovery patients of severe acute respiratory syndrome (SARS)before special plasma donation
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摘要 目的 探讨严重急性呼吸综合征 (SARS)康复者特殊献浆健康检查标准。方法 对志愿献浆的SARS康复者进行诊断确认、健康鉴定、常规献血前检查、血浆SARS冠状病毒荧光PCR检测及抗体ELISA检测。结果  4 5名志愿者中有 19名因健康状况或近期献血、或SARS抗体筛查阴性或其他原因未单采血浆 ,其余 2 6名分别每人单采血浆 2 0 0ml(1例为月经结束第 2天 ,1例ALT异常 ,2例Hb偏低 ,1例胸片轻度异常 ,4例肺功能轻度异常和 1例中度限制性通气功能障碍 ) ,30名志愿者血样SARS冠状病毒抗体检测 (稀释 8倍以上 )仍呈阳性反应 ;SARS病毒荧光PCR检测均为阴性。结论 对特殊志愿献浆的SARS康复者 ,部分健康检查标准可酌情放宽 ,是否存在SARS冠状病毒抗体是采浆与否的重要参考指标 。 Objective To study the special procedures of physical and laboratory examinations before plasmapheresis to the fully recovered patients of SARS.Methods 45 recovered patients who would donation plasma were evaluated for confirming the diagnosis,general physical examinations,SARS antibody (ELISA) and the fluorescent polymerase chain reaction (F PCR) to detect coronavirus.Results 19 out of 45 were unsuitable for plasmahperesis. The remaining 26 met the eligible criteria for plasma donation.Thirty of 31 plasma samples were positive for SARS antibody test,one negative.All samples from 26 collected plasma were negative for coronavirus.Conclusion It is sometimes necessary to adjust the eligibility criteria for special donors.It is very important to test SARS antibody prior to plasmapheresis.
出处 《中国输血杂志》 CAS CSCD 2003年第4期226-229,共4页 Chinese Journal of Blood Transfusion
基金 国家 8 63计划基金资助课题 (编号 :2 0 0 3AA2 0 810 4)
关键词 严重急性呼吸综合征 单采血浆 健康检查 冠状病毒 Severe acute respiratory syndrome (SARS) Plasmapheresis Physical examination Coronavirus
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