尿激酶型纤溶酶原激活物及其受体表达与胰腺癌浸润和转移的关系

THE EXPRESSION OF uPA AND uPAR AND ITS RELATION WITH INVASION AS WELL AS METASTASIS OF PANCREATIC CANCER

①目的 探讨尿激酶型纤溶酶原激活物 (uPA)与其特异性受体 (uPAR)在胰腺癌组织表达及与胰腺癌浸润和转移的关系。②方法 应用免疫组织化学PicTureTM法检测 8例正常胰腺和 4 7例胰腺癌组织中uPA和uPAR的表达。③结果 正常胰腺组织中uPA和uPAR均呈阴性表达 ,而胰腺癌组织中uPA和uPAR表达阳性率分别为5 7.4 % (2 7/47)和 5 1.1% (2 4 /47) ;二者与胰腺癌的浸润 (χ2 =5 .35、5 .0 0 ,P <0 .0 5 )和转移 (χ2 =7.5 2、6 .13,P <0 .0 5 )密切相关 ,而与胰腺癌的组织学分级无关 (χ2 =2 .5 3、2 .84 ,P >0 .0 5 ) ;uPA与uPAR表达呈显著正相关 (r =0 .86 ,χ2=10 .2 3,P <0 .0 1)。④结论 uPA uPAR系统的激活在胰腺癌浸润和转移过程中起重要作用。

Objective\ To study the expression of urokinase type plasminogen activator (uPA) and uPA receptor (uPAR) and investigate its relation with invasion and metastasis in pancreatic carcinoma. \ Methods\ uPA and uPAR in tissues of 47 cases of pancreatic carcinoma and eight normal pancreas were examined by immunohistochemical method. \ Results\ uPA and uPAR were negative in tissue of eight normal pancreas. The positive rates of uPA and uPAR in 47 cancer tissue were 57.4% and 51.1%, respectively, both were closely correlated with invasion ( χ 2=5.35,5.00,P <0.05) and metastasis ( χ 2=7.52,6.13,P <0.05),but no relation with histological grading noted ( χ 2=2.53,2.84,P >0.05). The expression of uPA was positively correlated with that of uPAR in pancreatic cancer ( r=0.86,χ 2=10.23,P <0.01). \ Conclusion\ The activation of uPA uPAR plays an important role in the process of invasion and metastasis of pancreatic carcinoma.