摘要
①目的 探讨肝病病人血清丙氨酸氨基转移酶 (ALT)、碱性磷酸酶 (ALP)活性变化对肝病的诊断意义。②方法 应用全自动生化分析仪 ,速率法测定 2 8例急性肝炎、2 4例慢性迁延性肝炎、18例慢性活动性肝炎、10例肝硬化、30例肝细胞性黄疸病人ALT、ALP活性 ,并与正常人进行对照。③结果 急性肝炎、慢性活动性肝炎、肝硬化、肝细胞性黄疸病人ALT、ALP含量均明显高于正常组 ,差异有显著性 (H =12 3.5 6、4 6 .36 ,q =3.0 9～ 18.2 5 ,P <0 .0 5、0 .0 1)。慢性迁延性肝炎病人ALP含量亦高于正常组 ,差异有显著性 (q =8.2 5 ,P <0 .0 1)。各组肝病病人ALT、ALP异常率均高于正常组 ,差异有显著性 (χ2 =8.4 0～ 76 .0 1,P <0 .0 1)。④结论 联合检测ALT和ALP对肝病诊断和鉴别诊断具有重要意义。
Objective\ To study the changes of activity of serum alanine transaminase(ALT) and alkaline phosphatase(ALP) in patients with liver diseases and its significance for the diagnosis.\ Methods\ The activity of serum ALT and ALP was measured by an analyzer in patients with the following diseases: acute hepatitis(28 cases), chronic persistent hepatitis(24), chronic active hepatitis(18), cirrhosis (10), and hepatocellular jaundice(30). The results were compared with healthy controls.\ Results The levels of ALT and ALP in patients with acute hepatitis, chronic active hepatitis, cirrhosis and hepatocellular jaundice were higher than normal controls, the difference was significant ( H=123.56, 46.36, q=3.09-18.25, P < 0.05 , 0.01). The level of ALP in chronic persistent hepatitis was higher than normal controls as well ( q=8.25,P < 0.01 ). The abnormality of both ALP and ALT in patients with diseases mentioned above was higher than the controls, the difference was marked ( χ 2=8.40-76.01, P < 0.01 ). \ Conclusion\ Combined detection of both ALT and ALP is of great significance in the diagnosis and differential diagnosis of diseases in the liver.
出处
《青岛大学医学院学报》
CAS
2003年第3期337-338,共2页
Acta Academiae Medicinae Qingdao Universitatis
